Background: Orthostatic hypotension (OH) is associated with a higher risk of mortality in the general population; however, it has not been studied in the cancer population. This study aimed to assess the prevalence of OH in cancer patients compared to that in the noncancer population. Methods: A total of 411 patients (mean age 63.5 ± 10.6 years) were recruited: patients with active cancer (n= 223) and patients hospitalised for other reasons, but without a cancer diagnosis (n= 188). Medical histories were collected and an orthostatic challenge test was performed. OH was defined as a blood pressure (BP) decrease upon standing of ≥20 mmHg for the systolic or ≥10 mmHg for the diastolic BP after 1 or 3 min; or a systolic BP decrease <90 mmHg. Results: The prevalence of OH in the subjects with cancer was significantly higher than in the subjects without cancer (28.7% vs. 16.5%, respectively,p= 0.003). OH was the most common in the lung cancer patients (57.5%). In a single-variable analysis, the predictors of OH were cancer presence, age ≥ 65 years, and body mass index (BMI) ≥ 30 kg/m2. In the multivariable model, the strongest independent predictor of OH was cancer status, which doubled the risk of OH, and BMI ≥ 30 kg/m2and diabetes. Conclusions: Cancer patients are characterised by a high prevalence of OH. In this population, the recommendation of routine orthostatic challenge tests should be considered.
背景：在普通人群中，体位性低血压（OH）与较高的死亡风险相关；然而，在癌症人群中尚未对此进行研究。本研究旨在评估癌症患者与非癌症人群中OH的患病率。方法：共招募411名患者（平均年龄63.5±10.6岁），包括活动性癌症患者（n=223）和因其他原因住院但未诊断为癌症的患者（n=188）。收集了患者的病史，并进行了体位挑战测试。OH定义为站立后1或3分钟内收缩压下降≥20 mmHg或舒张压下降≥10 mmHg；或收缩压下降至<90 mmHg。结果：癌症患者中OH的患病率显著高于非癌症患者（分别为28.7% vs. 16.5%，p=0.003）。OH在肺癌患者中最为常见（57.5%）。在单变量分析中，OH的预测因素包括癌症存在、年龄≥65岁和体重指数（BMI）≥30 kg/m²。在多变量模型中，OH最强的独立预测因素是癌症状态，其使OH风险增加一倍，以及BMI≥30 kg/m²和糖尿病。结论：癌症患者中OH患病率较高。在这一人群中，应考虑推荐常规进行体位挑战测试。
The Prevalence of Orthostatic Hypotension in Cancer Patients
肿瘤(癌症)患者之家