This study explores the previously uncharted territory of the effects of ultraviolet (UV) radiation on diabetic skin, compared to its well-documented impact on normal skin, particularly focusing on carcinogenesis and aging. Employing hairless SKH-hr2, Type 1 and 2 diabetic, and nondiabetic male mice, the research subjected these to UV radiation thrice weekly for eight months. The investigation included comprehensive assessments of photoaging and photocarcinogenesis in diabetic versus normal skin, measuring factors such as hydration, trans-epidermal water loss, elasticity, skin thickness, melanin, sebum content, stratum corneum exfoliation and body weight, alongside photo documentation. Additionally, oxidative stress and the presence of hydrophilic antioxidants (uric acid and glutathione) in the stratum corneum were evaluated. Histopathological examination post-sacrifice provided insights into the morphological changes. Findings reveal that under UV exposure, Type 1 diabetic skin showed heightened dehydration, thinning, and signs of accelerated aging. Remarkably, Type 1 diabetic mice did not develop squamous cell carcinoma or pigmented nevi, contrary to normal and Type 2 diabetic skin. This unexpected resistance to UV-induced skin cancers in Type 1 diabetic skin prompts a crucial need for further research to uncover the underlying mechanisms providing this resistance.
本研究探索了紫外线辐射对糖尿病皮肤的影响，这一领域此前尚未被充分研究，并与已明确记载的对正常皮肤的影响（尤其聚焦于致癌与老化过程）进行比较。实验采用无毛SKH-hr2小鼠模型，包括1型糖尿病、2型糖尿病及非糖尿病雄性小鼠，使其在八个月内每周接受三次紫外线照射。研究系统评估了糖尿病皮肤与正常皮肤在光老化和光致癌方面的差异，检测指标包括皮肤水合度、经皮水分流失、弹性、厚度、黑色素含量、皮脂分泌、角质层脱落情况及体重变化，并辅以影像记录。同时，对角质层中的氧化应激水平及亲水性抗氧化剂（尿酸与谷胱甘肽）含量进行了测定。处死后通过组织病理学检查揭示了皮肤形态学改变。研究结果显示，在紫外线暴露下，1型糖尿病皮肤表现出更严重的脱水、变薄及加速老化迹象。值得注意的是，与正常皮肤及2型糖尿病皮肤相反，1型糖尿病小鼠未出现鳞状细胞癌或色素痣。1型糖尿病皮肤对紫外线诱发皮肤癌的这种意外抵抗性，提示亟需进一步研究以揭示其潜在保护机制。
Type I Diabetes Mellitus Suppresses Experimental Skin Carcinogenesis
肿瘤(癌症)患者之家