Background: Prostate cancer is a prevalent cancer among men. Multiparametric ultrasound [mpUS] is a diagnostic instrument that uses various types of ultrasounds to diagnose it. This systematic review aims to evaluate the performance of different parametric ultrasounds in diagnosing prostate cancer by associating with radical prostatectomy specimens. Methodology: A review was performed on various ultrasound parameters using five databases. Systematic review tools were utilized to eliminate duplicates and identify relevant results. Reviewers used the Quality Assessment of Diagnostic Accuracy Results [QUADAS-2] to evaluate the bias and applicability of the study outcomes. Result: Between 2012 and 2023, eleven studies were conducted to evaluate the performance of the different ultrasound parametric procedures in detecting prostate cancer using grayscale TRUS, SWE, CEUS, and mpUS. The high sensitivity of these procedures was found at 55%, 88.6%, 81%, and 74%, respectively. The specificity of these procedures was found to be 93.4%, 97%, 88%, and 59%, respectively. This high sensitivity and specificity may be associated with the large lesion size. The studies revealed that the sensitivity of these procedures in diagnosing clinically significant prostate cancer was 55%, 73%, 70%, and 74%, respectively, while the specificity was 61%, 78.2%, 62%, and 59%, respectively. Conclusions: The mpUS procedure provides high sensitivity and specificity in PCa detection, especially for clinically significant prostate cancer.
背景：前列腺癌是男性常见的恶性肿瘤。多参数超声是一种通过整合多种超声模式进行诊断的检测手段。本系统综述旨在通过关联根治性前列腺切除术标本，评估不同参数超声在前列腺癌诊断中的效能。 方法：通过五个数据库对各类超声参数研究进行文献检索。采用系统综述工具剔除重复文献并筛选相关研究。评审人员使用诊断准确性研究质量评估工具（QUADAS-2）对研究结果的偏倚风险和适用性进行评价。 结果：2012年至2023年间，共纳入11项研究评估灰阶经直肠超声、剪切波弹性成像、超声造影及多参数超声在检测前列腺癌中的表现。上述方法的敏感度分别为55%、88.6%、81%和74%，特异度分别为93.4%、97%、88%和59%。这种高敏感度与特异度可能与病灶体积较大相关。研究显示，上述方法对临床显著性前列腺癌的诊断敏感度分别为55%、73%、70%和74%，特异度分别为61%、78.2%、62%和59%。 结论：多参数超声在前列腺癌检测中具有较高的敏感度和特异度，尤其对临床显著性前列腺癌的诊断价值更为突出。
肿瘤(癌症)患者之家