文章：

胰腺神经内分泌肿瘤外科治疗的现代策略

Contemporary Approaches to the Surgical Management of Pancreatic Neuroendocrine Tumors

原文发布日期：14 April 2024

DOI: 10.3390/cancers16081501

类型: Article

开放获取: 是

英文摘要：

The incidence of pancreatic neuroendocrine tumors (PNETs) is on the rise primarily due to the increasing use of cross-sectional imaging. Most of these incidentally detected lesions are non-functional PNETs with a small proportion of lesions being hormone-secreting, functional neoplasms. With recent advances in surgical approaches and systemic therapies, the management of PNETs have undergone a paradigm shift towards a more individualized approach. In this manuscript, we review the histologic classification and diagnostic approaches to both functional and non-functional PNETs. Additionally, we detail multidisciplinary approaches and surgical considerations tailored to the tumor’s biology, location, and functionality based on recent evidence. We also discuss the complexities of metastatic disease, exploring liver-directed therapies and the evolving landscape of minimally invasive surgical techniques.

摘要翻译： 

胰腺神经内分泌肿瘤（PNETs）的发病率呈上升趋势，这主要归因于横断面影像学检查的广泛应用。大多数偶然发现的病变为非功能性PNETs，仅少数为激素分泌型功能性肿瘤。随着外科手术方式和全身治疗手段的进展，PNETs的治疗模式已转向更加个体化的管理策略。本文综述了功能性与非功能性PNETs的组织学分类及诊断方法，并基于最新证据详细阐述了针对肿瘤生物学特性、解剖位置和功能状态的多学科诊疗策略及外科考量。同时，本文探讨了转移性疾病的复杂性，分析了肝脏定向治疗及微创外科技术的演进趋势。

原文链接：

Contemporary Approaches to the Surgical Management of Pancreatic Neuroendocrine Tumors