Heat shock proteins (Hsps) are involved in one of the adaptive mechanisms protecting cells against environmental and metabolic stress. Moreover, the large role of these proteins in the carcinogenesis process, as well as in chemoresistance, was noticed. This review aims to draw attention to the possibilities of using Hsps in developing new cancer therapy methods, as well as to indicate directions for future research on this topic. In order to discuss this matter, a thorough review of the latest scientific literature was carried out, taking into account the importance of selected proteins from the Hsp family, including Hsp27, Hsp40, Hsp60, Hsp70, Hsp90 and Hsp110. One of the more characteristic features of all Hsps is that they play a multifaceted role in cancer progression, which makes them an obvious target for modern anticancer therapy. Some researchers emphasize the importance of directly inhibiting the action of these proteins. In turn, others point to their possible use in the design of cancer vaccines, which would work by inducing an immune response in various types of cancer. Due to these possibilities, it is believed that the use of Hsps may contribute to the progress of oncoimmunology, and thus help in the development of modern anticancer therapies, which would be characterized by higher effectiveness and lower toxicity to the patients.
热休克蛋白（Hsps）作为细胞应对环境和代谢应激的适应性机制之一，在细胞保护过程中发挥着重要作用。值得注意的是，这类蛋白在肿瘤发生及化疗耐药过程中亦具有重要影响。本综述旨在探讨利用热休克蛋白开发新型癌症治疗策略的潜在可能，并为该领域的未来研究方向提供思路。通过系统梳理最新科学文献，本文重点分析了Hsp27、Hsp40、Hsp60、Hsp70、Hsp90及Hsp110等热休克蛋白家族关键成员的功能特性。所有热休克蛋白的共同特征在于其在癌症进展中扮演多维度角色，这使其成为现代抗癌治疗的理想靶点。部分学者强调直接抑制这些蛋白活性的重要性，而另一些研究则指出其在癌症疫苗设计中的应用潜力——通过诱导针对多种癌症的免疫应答发挥作用。基于这些特性，热休克蛋白的应用有望推动肿瘤免疫学的发展，进而促进高效低毒的现代抗癌疗法的创新。
肿瘤(癌症)患者之家