Breast cancer is the leading cause of cancer-related mortality among women in Germany and worldwide. This retrospective claims data analysis utilizing data from AOK Baden-Wuerttemberg, a major statutory German health insurance provider, aimed to construct and assess a real-world data breast cancer disease model. The study included 27,869 female breast cancer patients and 55,738 age-matched controls, analyzing data from 2010 to 2020. Three distinct breast cancer stages were analyzed: Stage A (early breast cancer without lymph node involvement), Stage B (early breast cancer with lymph node involvement), and Stage C (primary distant metastatic breast cancer). Tumor subtypes were estimated based on the prescription of antihormonal or HER2-targeted therapy. The study established that 77.9% of patients had HR+ breast cancer and 9.8% HER2+; HR+/HER2− was the most common subtype (70.9%). Overall survival (OS) analysis demonstrated significantly lower survival rates for stages B and C than for controls, with 5-year OS rates ranging from 79.3% for stage B to 35.4% for stage C. OS rates were further stratified by tumor subtype and stage, revealing varying prognoses. Distant recurrence-free survival (DRFS) analysis showed higher recurrence rates in stage B than in stage A, with HR−/HER2− displaying the worst DRFS. This study, the first to model breast cancer subtypes, stages, and outcomes using German claims data, provides valuable insights into real-world breast cancer epidemiology and demonstrates that this breast cancer disease model has the potential to be representative of treatment outcomes.
乳腺癌是德国乃至全球女性癌症相关死亡的主要原因。本研究利用德国主要法定健康保险提供商AOK巴登-符腾堡州的理赔数据，通过回顾性索赔数据分析，旨在构建并评估一个真实世界数据的乳腺癌疾病模型。研究纳入27,869名女性乳腺癌患者和55,738名年龄匹配的对照组，分析了2010年至2020年的数据。研究分析了三种不同的乳腺癌分期：A期（无淋巴结受累的早期乳腺癌）、B期（有淋巴结受累的早期乳腺癌）和C期（原发性远处转移性乳腺癌）。肿瘤亚型根据抗激素或HER2靶向治疗的处方进行估算。研究确定77.9%的患者为HR+乳腺癌，9.8%为HER2+；HR+/HER2−是最常见的亚型（70.9%）。总生存期（OS）分析显示，B期和C期患者的生存率显著低于对照组，5年OS率从B期的79.3%到C期的35.4%不等。根据肿瘤亚型和分期进一步分层分析OS率，揭示了不同的预后。远处无复发生存期（DRFS）分析显示，B期的复发率高于A期，其中HR−/HER2−亚型的DRFS最差。这项研究首次利用德国理赔数据对乳腺癌亚型、分期和结局进行建模，为真实世界乳腺癌流行病学提供了宝贵见解，并证明该乳腺癌疾病模型具有代表治疗结局的潜力。
肿瘤(癌症)患者之家