文章：

头颈部鳞状细胞癌诊断时血浆IL-1和IL-6家族细胞因子及可溶性受体水平分析：高水平预示五年疾病特异性生存率与总生存率降低

Plasma IL-1 and IL-6 Family Cytokines with Soluble Receptor Levels at Diagnosis in Head and Neck Squamous Cell Carcinoma: High Levels Predict Decreased Five-Year Disease-Specific and Overall Survival

原文发布日期：12 April 2024

DOI: 10.3390/cancers16081484

类型: Article

开放获取: 是

英文摘要：

Activation of the acute-phase cascade (APC) has been correlated with outcomes in various cancers, including head and neck squamous cell carcinoma (HNSCC). Primary drivers of the APC are the cytokines within the interleukin-6 (IL-6) and IL-1 families. Plasma levels of IL-6 family cytokines/soluble receptors (IL-6, IL-27, IL-31, OSM, CNTF, soluble (s-)gp130, s-IL-6Rα) and IL-1 family members (IL-1RA, s-IL-33Rα) were determined at diagnosis for 87 human papillomavirus (HPV)-negative (−) HNSCC patients. We then studied the 5-year Disease-Specific Survival (DSS) and Overall Survival (OS). Increased plasma levels of IL-6 (p< 0.001/p< 0.001) (DSS/OS), IL-31 (p= 0.044/p= 0.07), IL-1RA (p= 0.004/p= 0.035), soluble (s)-IL-6Rαp= 0.022/p= 0.035), and s-gp130 (p= 0.007/p= 0.003) at diagnosis were predictors of both OS and DSS from HPV(−) HNSCC patients. The cytokine DSS/OS predictions were associated with TNM stage and smoking history, whereas the soluble receptors IL-6Rα, gp130, and IL33Rα more uniquely predicted DSS/OS. Clinically, IL-6 levels above 2.5 pg/mL yielded 75% specificity and 70% sensitivity for DSS. In conclusion, high plasma levels of IL-6, IL-31, and IL-1RA, as well as the soluble receptors IL-6Rα, gp130, and IL33Rα, predicted clinical outcome. This shows their potential as candidates for both general therapy and immune therapy stratification, as well as being future platforms for the development of new immunotherapy.

摘要翻译： 

急性期反应级联（APC）的激活与多种癌症（包括头颈部鳞状细胞癌[HNSCC]）的预后相关。APC的主要驱动因子是白细胞介素-6（IL-6）和IL-1家族内的细胞因子。本研究检测了87名人乳头瘤病毒（HPV）阴性（−）HNSCC患者在确诊时血浆中IL-6家族细胞因子/可溶性受体（IL-6、IL-27、IL-31、OSM、CNTF、可溶性[s-]gp130、s-IL-6Rα）及IL-1家族成员（IL-1RA、s-IL-33Rα）的水平，并分析了其与5年疾病特异性生存率（DSS）和总生存率（OS）的关系。结果显示，确诊时血浆中IL-6（p<0.001/p<0.001，DSS/OS）、IL-31（p=0.044/p=0.07）、IL-1RA（p=0.004/p=0.035）、可溶性IL-6Rα（p=0.022/p=0.035）以及s-gp130（p=0.007/p=0.003）水平的升高是HPV阴性HNSCC患者OS和DSS的预测因子。细胞因子对DSS/OS的预测与TNM分期和吸烟史相关，而可溶性受体IL-6Rα、gp130和IL33Rα则更独立地预测DSS/OS。在临床应用中，IL-6水平高于2.5 pg/mL对DSS的预测具有75%的特异性和70%的敏感性。综上所述，高血浆水平的IL-6、IL-31和IL-1RA，以及可溶性受体IL-6Rα、gp130和IL33Rα，能够预测临床结局。这表明它们有潜力作为通用治疗和免疫治疗分层的候选指标，并为开发新型免疫疗法提供未来平台。

原文链接：

Plasma IL-1 and IL-6 Family Cytokines with Soluble Receptor Levels at Diagnosis in Head and Neck Squamous Cell Carcinoma: High Levels Predict Decreased Five-Year Disease-Specific and Overall Survival