The role of CD10 expression in colorectal cancer has been controversially discussed in the literature. Some data suggest a predictive capacity for lymph node and liver metastases, thus influencing overall survival (OS) and disease-free survival (DFS). This study aims to analyse the relationship between CD10 expression and overall survival (OS) in a European cohort. To determine the association of CD10 expression with tumour phenotype, molecular features, and prognosis, a tissue microarray of 1469 colorectal carcinomas was analysed using immunohistochemistry and was compared with matched clinicopathologic data. CD10 expression correlated with earlier tumour stages (p= 0.017) and left-sided colon cancer (p< 0.001). However, no correlation was found between CD10 expression and lymph node involvement (p= 0.711), tumour grading (p= 0.397), or overall survival (p= 0.562). Even in the subgroup analysis of tumour or nodal stage, CD10 did not affect overall survival, although it was significantly associated with p53 and nuclear β-catenin expression (p= 0.013 andp< 0.001, respectively). CD10 expression correlates with earlier tumour stages, colon cancer location, and indicators of aggressive CRC subtypes. However, we can exclude CD10 as a relevant independent prognosticator for CRC.
CD10在结直肠癌中的作用在文献中存在争议。部分数据表明其对淋巴结和肝转移具有预测能力，从而影响总生存期（OS）和无病生存期（DFS）。本研究旨在分析欧洲队列中CD10表达与总生存期（OS）的关系。为明确CD10表达与肿瘤表型、分子特征及预后的关联，本研究采用免疫组织化学方法对1469例结直肠癌组织芯片进行分析，并与匹配的临床病理数据进行比较。CD10表达与较早的肿瘤分期（p=0.017）及左侧结肠癌（p<0.001）相关。然而，CD10表达与淋巴结转移（p=0.711）、肿瘤分级（p=0.397）或总生存期（p=0.562）均无显著相关性。即使在肿瘤分期或淋巴结分期的亚组分析中，CD10也未影响总生存期，尽管其与p53及核β-连环蛋白表达显著相关（p值分别为0.013和<0.001）。CD10表达与较早的肿瘤分期、结肠癌位置及侵袭性结直肠癌亚型的标志物相关。然而，我们可以排除CD10作为结直肠癌相关独立预后因素的可能性。
肿瘤(癌症)患者之家