Background. Pseudomyxoma peritonei (PMP) is a rare, progressive, slowly growing, inadequately understood neoplasm with a 5-year progression-free survival rate of as low as 48%. It is characterized by varying degrees of malignancy and the production of mucinous and gelatinous structures. Typically, the development of pseudomyxoma peritonei is associated with the rupture of appendiceal mucinous tumors and other gastrointestinal or ovarian mucinous tumors. The goal of our literature review was to identify various aspects that characterize the ovarian causes of pseudomyxoma peritonei. Materials and methods. The authors performed an extensive literature search between 1 February 2024 and 2 March 2024 on the following databases: Pubmed, Scopus, Oxford Journals, and Reaxys, and the findings were summarized into seven main clinical and paraclinical situations. Results. According to our research, the main instances in which pseudomyxoma peritonei can be triggered by an ovarian cause are the following: (1) mucinous cystadenoma; (2) mucinous ovarian cancer; (3) colon cancer with ovarian metastasis; (4) malignant transformation of an ovarian primary mature cystic teratoma; (5) appendiceal mucocele with peritoneal dissemination mimicking an ovarian tumor with peritoneal carcinomatosis; (6) mucinous borderline tumor developing inside an ovarian teratoma; and (7) the association between a mucinous bilateral ovarian cancer and a colonic tumor. Conclusions. In our study, we aimed to provide a comprehensive overview of the ovarian causes of pseudomyxoma peritonei, including its epidemiology, imagery characteristics, symptoms, current treatment, and promising future therapies, in the hopes of finding feasible solutions, as a lack of understanding of this mucus-secreting malignant disease increases the risk of delayed diagnosis or uncontrolled deterioration.
背景：腹膜假性黏液瘤是一种罕见、进展缓慢且认知不足的肿瘤，其5年无进展生存率可低至48%。该疾病以不同程度的恶性特征及黏液性、胶冻样结构形成为特点。通常，腹膜假性黏液瘤的发生与阑尾黏液性肿瘤及其他胃肠道或卵巢黏液性肿瘤的破裂相关。本文献综述旨在系统梳理卵巢源性腹膜假性黏液瘤的临床特征。材料与方法：作者于2024年2月1日至3月2日期间，在PubMed、Scopus、Oxford Journals及Reaxys数据库进行了全面文献检索，并将研究结果归纳为七类主要临床与辅助临床情况。结果：研究表明，卵巢源性腹膜假性黏液瘤主要见于以下情况：(1)黏液性囊腺瘤；(2)卵巢黏液性癌；(3)结肠癌伴卵巢转移；(4)卵巢原发性成熟囊性畸胎瘤恶变；(5)阑尾黏液囊肿伴腹膜播散（拟似卵巢肿瘤伴腹膜癌病）；(6)卵巢畸胎瘤内发生的黏液性交界性肿瘤；(7)双侧卵巢黏液性癌合并结肠肿瘤。结论：本研究系统综述了卵巢源性腹膜假性黏液瘤的流行病学、影像学特征、临床症状、现行治疗方案及未来潜在疗法。由于对该黏液分泌性恶性疾病的认识不足可能导致延误诊断或病情失控，本研究旨在为探寻可行的诊疗方案提供理论依据。
Ovarian Causes of Pseudomyxoma Peritonei (PMP)—A Literature Review
肿瘤(癌症)患者之家