Indoor radon is an important risk factor for lung cancer, as 3–14% of lung cancer cases can be attributed to radon. The aim of our study was to estimate the impact of indoor radon exposure on lung cancer incidence over the last 40 years in Slovenia. We analyzed the distribution of lung cancer incidence across 212 municipalities and 6032 settlements in Slovenia. The standardized incidence ratios were smoothed with the Besag–York–Mollie model and fitted with the integrated nested Laplace approximation. A categorical explanatory variable, the risk of indoor radon exposure with low, moderate and high risk values, was added to the models. We also calculated the population attributable fraction. Between 2.8% and 6.5% of the lung cancer cases in Slovenia were attributable to indoor radon exposure, with values varying by time period. The relative risk of developing lung cancer was significantly higher among the residents of areas with a moderate and high risk of radon exposure. Indoor radon exposure is an important risk factor for lung cancer in Slovenia in areas with high natural radon radiation (especially in the southern and south-eastern parts of the country).
室内氡是肺癌的重要危险因素，3-14%的肺癌病例可归因于氡暴露。本研究旨在评估斯洛文尼亚过去40年间室内氡暴露对肺癌发病率的影响。我们分析了斯洛文尼亚212个市镇及6032个聚居区的肺癌发病分布情况。采用Besag-York-Mollie模型对标准化发病率进行平滑处理，并通过集成嵌套拉普拉斯近似法进行拟合。在模型中加入了室内氡暴露风险等级（低风险、中风险、高风险）这一分类解释变量，同时计算了人群归因分数。结果显示，斯洛文尼亚2.8%-6.5%的肺癌病例可归因于室内氡暴露，具体数值随时间阶段而变化。在中高风险氡暴露区域，居民罹患肺癌的相对风险显著升高。在天然氡辐射水平较高地区（特别是该国南部和东南部），室内氡暴露是斯洛文尼亚肺癌发病的重要危险因素。
Impact of Indoor Radon Exposure on Lung Cancer Incidence in Slovenia
肿瘤(癌症)患者之家