Pediatric cancers are the leading cause of disease-related deaths in children and adolescents. Most of these tumors are difficult to treat and have poor overall survival. Concerns have also been raised about drug toxicity and long-term detrimental side effects of therapies. In this review, we discuss the advantages and unique attributes of zebrafish as pediatric cancer models and their importance in targeted drug discovery and toxicity assays. We have also placed a special focus on zebrafish models of pediatric brain cancers—the most common and difficult solid tumor to treat.
儿童癌症是导致儿童和青少年疾病相关死亡的主要原因。这类肿瘤大多难以治疗，总体生存率较低。同时，治疗过程中的药物毒性及长期副作用也引发广泛关注。本综述探讨了斑马鱼作为儿童癌症模型的优势与独特价值，及其在靶向药物发现与毒性检测中的重要作用。我们特别聚焦于儿童脑肿瘤的斑马鱼模型——作为最常见且最难治疗的实体肿瘤，其研究具有特殊意义。
Zebrafish—A Suitable Model for Rapid Translation of Effective Therapies for Pediatric Cancers
肿瘤(癌症)患者之家