Background: Risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) are the most effective breast and ovarian cancer preventive interventions. EQ-5D is the recommended tool to assess the quality of life and determine health-related utility scores (HRUSs), yet there are no published EQ-5D HRUSs after these procedures. These are essential for clinicians counselling patients and for health-economic evaluations. Methods: We used aggregate data from our published systematic review and converted SF-36/SF-12 summary scores to EQ-5D HRUSs using a published mapping algorithm. Study control arm or age-matched country-specific reference values provided comparison. Random-effects meta-analysis provided adjusted disutilities and utility scores. Subgroup analyses included long-term vs. short-term follow-up. Results: Four studies (209 patients) reported RRM outcomes using SF-36, and five studies (742 patients) reported RRSO outcomes using SF-12/SF-36. RRM is associated with a long-term (>2 years) disutility of −0.08 (95% CI −0.11, −0.04) (I231.4%) and a utility of 0.92 (95% CI 0.88, 0.95) (I231.4%). RRSO is associated with a long-term (>1 year) disutility of −0.03 (95% CI −0.05, 0.00) (I217.2%) and a utility of 0.97 (95% CI 0.94, 0.99) (I234.0%). Conclusions: We present the first HRUSs sourced from patients following RRM and RRSO. There is a need for high-quality prospective studies to characterise quality of life at different timepoints.
背景：降低风险的乳腺切除术（RRM）和降低风险的输卵管卵巢切除术（RRSO）是预防乳腺癌和卵巢癌最有效的干预措施。EQ-5D是评估生活质量和确定健康相关效用评分（HRUSs）的推荐工具，但目前尚无关于这些手术后EQ-5D HRUSs的公开数据。这些数据对于临床医生为患者提供咨询以及进行卫生经济学评估至关重要。 方法：我们使用已发表系统综述中的汇总数据，并通过已发布的映射算法将SF-36/SF-12总分转换为EQ-5D HRUSs。研究对照组或年龄匹配的国家特定参考值提供了比较依据。随机效应荟萃分析提供了调整后的负效用和效用评分。亚组分析包括长期与短期随访。 结果：四项研究（209名患者）使用SF-36报告了RRM的结果，五项研究（742名患者）使用SF-12/SF-36报告了RRSO的结果。RRM与长期（>2年）负效用-0.08（95% CI -0.11, -0.04）（I² 31.4%）和效用评分0.92（95% CI 0.88, 0.95）（I² 31.4%）相关。RRSO与长期（>1年）负效用-0.03（95% CI -0.05, 0.00）（I² 17.2%）和效用评分0.97（95% CI 0.94, 0.99）（I² 34.0%）相关。 结论：我们首次提供了源自RRM和RRSO术后患者的HRUSs。有必要进行高质量的前瞻性研究，以描述不同时间点的生活质量特征。
肿瘤(癌症)患者之家