Although cancer and ischemic heart disease (IHD) frequently manifest in the same individual, the risk of IHD events in cancer, especially head and neck cancer (HNC), remains unclear. We aimed to examine the incidence and risk of IHD events in patients with HNC using a population-based cohort dataset in South Korea (2002–2013). Through rigorous propensity score matching, we compared data from 2816 individuals without HNC and 704 individuals with HNC. Key independent variables were matched between groups, and the Charlson Comorbidity Index was used to match comorbidities. The Kaplan–Meier method depicted the cumulative probability of IHD throughout the follow-up period for both the study and control groups. The overall IHD incidence was significantly higher (19.93) in patients with HNC than in those without HNC (14.81), signifying an augmented IHD risk in the HNC cohort. Subsequent temporal analysis revealed a significant surge in IHD risk commencing 4 years after HNC diagnosis and persisting throughout the follow-up period. Subgroup analysis revealed an increased IHD risk in men with HNC and patients with cancers affecting the oral and sinonasal regions. This retrospective cohort study provides valuable scientific insights into the nuanced relationship between HNC and IHD, underscoring the need for tailored monitoring protocols and specialized care for susceptible individuals.
尽管癌症与缺血性心脏病常发生于同一患者，但癌症患者（尤其是头颈癌患者）发生缺血性心脏病事件的风险仍不明确。本研究旨在利用韩国基于人群的队列数据集（2002-2013年）探讨头颈癌患者缺血性心脏病事件的发生率及风险。通过严格的倾向评分匹配，我们比较了2816名非头颈癌个体与704名头颈癌患者的数据。关键自变量在组间实现匹配，并采用查尔森合并症指数对合并症进行匹配。通过Kaplan-Meier法描绘了研究组与对照组在整个随访期间缺血性心脏病的累积发生概率。头颈癌患者总体缺血性心脏病发生率（19.93）显著高于非头颈癌人群（14.81），表明头颈癌队列的缺血性心脏病风险显著增加。后续时间分析显示，从头颈癌确诊后第4年开始，缺血性心脏病风险显著上升，并持续贯穿整个随访期。亚组分析表明，男性头颈癌患者以及口腔和鼻窦区域癌症患者的缺血性心脏病风险更高。这项回顾性队列研究为深入理解头颈癌与缺血性心脏病之间的复杂关系提供了重要科学依据，强调需要对易感人群制定个体化监测方案并提供专业医疗照护。
肿瘤(癌症)患者之家