Endometrial cancer is the most common gynecologic cancer in the United States and it contributes to the second most gynecologic cancer-related deaths. With upfront surgery, the specific characteristics of both the patient and tumor allow for risk-tailored treatment algorithms including adjuvant radiotherapy and systemic therapy. In this narrative review, we discuss the current radiation treatment paradigm for endometrial cancer with an emphasis on various radiotherapy modalities, techniques, and dosing regimens. We then elaborate on how to tailor radiotherapy treatment courses in combination with other cancer-directed treatments, including chemotherapy and immunotherapy. In conclusion, this review summarizes ongoing research that aims to further individualize radiotherapy regimens for individuals in an attempt to improve patient outcomes.
子宫内膜癌是美国最常见的妇科恶性肿瘤，其导致的妇科癌症相关死亡人数位居第二。通过前期手术，结合患者与肿瘤的具体特征，可制定个体化风险分层治疗方案，包括辅助放疗和全身性治疗。本文通过叙述性综述，探讨当前子宫内膜癌的放射治疗模式，重点阐述不同放疗方式、技术及剂量方案。进而详细论述如何将放疗疗程与化疗、免疫治疗等其他抗癌治疗相结合进行个体化设计。最后，本文总结了当前旨在进一步实现放疗方案个体化、以改善患者预后的相关研究方向。
Risk-Tailoring Radiotherapy for Endometrial Cancer: A Narrative Review
肿瘤(癌症)患者之家