文章：

乳腺癌中的NDRGs：综述与计算机模拟分析

NDRGs in Breast Cancer: A Review and In Silico Analysis

原文发布日期：29 March 2024

DOI: 10.3390/cancers16071342

类型: Article

开放获取: 是

英文摘要：

The N-myc downstream regulated gene family (NDRGs) includes four members:NDRG1,NDRG2,NDRG3, andNDRG4. These members exhibit 53–65% amino acid identity. The role of NDRGs in tumor growth and metastasis appears to be tumor- and context-dependent. While many studies have reported that these family members have tumor suppressive roles, recent studies have demonstrated that NDRGs, particularlyNDRG1andNDRG2, function as oncogenes, promoting tumor growth and metastasis. Additionally, NDRGs are involved in regulating different signaling pathways and exhibit diverse cellular functions in breast cancers. In this review, we comprehensively outline the oncogenic and tumor suppressor roles of the NDRG family members in breast cancer, examining evidence from in vitro and in vivo breast cancer models as well as tumor tissues from breast cancer patients. We also present analyses of publicly available genomic and transcriptomic data from multiple independent cohorts of breast cancer patients.

摘要翻译： 

N-myc下游调节基因家族（NDRGs）包含四个成员：NDRG1、NDRG2、NDRG3和NDRG4。这些成员间氨基酸序列同源性达53%-65%。NDRGs在肿瘤生长和转移中的作用具有肿瘤类型及环境依赖性。尽管大量研究报道该家族成员具有肿瘤抑制作用，但近期研究表明NDRGs（特别是NDRG1和NDRG2）可作为癌基因促进肿瘤生长与转移。此外，NDRGs参与调控多种信号通路，并在乳腺癌中展现出多样化的细胞功能。本综述系统阐述了NDRG家族成员在乳腺癌中的促癌与抑癌双重作用，整合了体外与体内乳腺癌模型以及乳腺癌患者肿瘤组织的实验证据，并基于多个独立乳腺癌患者队列的公开基因组与转录组数据进行了深入分析。

原文链接：

NDRGs in Breast Cancer: A Review and In Silico Analysis