Metastasis remains the most critical factor limiting patient survival and the most challenging part of cancer-targeted therapy. Identifying the causal drivers of metastasis and characterizing their properties in various key aspects of cancer biology is essential for the development of novel metastasis-targeting approaches. Metastasis-associated in colon cancer 1 (MACC1) is a prognostic and predictive biomarker that is now recognized in more than 20 cancer entities. Although MACC1 can already be linked with many hallmarks of cancer, one key process—the facilitation of immune evasion—remains poorly understood. In this review, we explore the direct and indirect links between MACC1 and the mechanisms of immune escape. Therein, we highlight the signaling pathways and secreted factors influenced by MACC1 as well as their effects on the infiltration and anti-tumor function of immune cells.
转移仍是限制患者生存的最关键因素，也是癌症靶向治疗最具挑战性的环节。识别转移的驱动因素并阐明其在癌症生物学多个关键层面的特性，对于开发新型转移靶向疗法至关重要。结肠癌转移相关基因1（MACC1）作为预后与预测性生物标志物，已在超过20种癌症类型中得到确认。尽管MACC1已被证实与癌症的诸多特征相关，但其在关键过程——促进免疫逃逸中的作用机制仍不明确。本综述系统探讨了MACC1与免疫逃逸机制之间的直接与间接关联，重点阐述了MACC1调控的信号通路及分泌因子如何影响免疫细胞浸润及其抗肿瘤功能。
肿瘤(癌症)患者之家