文章：

利用药理学抑制剂靶向癌症中失调的脂质代谢

Targeting Dysregulated Lipid Metabolism in Cancer with Pharmacological Inhibitors

原文发布日期：28 March 2024

DOI: 10.3390/cancers16071313

类型: Article

开放获取: 是

英文摘要：

Metabolic plasticity is recognised as a hallmark of cancer cells, enabling adaptation to microenvironmental changes throughout tumour progression. A dysregulated lipid metabolism plays a pivotal role in promoting oncogenesis. Oncogenic signalling pathways, such as PI3K/AKT/mTOR, JAK/STAT, Hippo, and NF-kB, intersect with the lipid metabolism to drive tumour progression. Furthermore, altered lipid signalling in the tumour microenvironment contributes to immune dysfunction, exacerbating oncogenesis. This review examines the role of lipid metabolism in tumour initiation, invasion, metastasis, and cancer stem cell maintenance. We highlight cybernetic networks in lipid metabolism to uncover avenues for cancer diagnostics, prognostics, and therapeutics.

摘要翻译： 

代谢可塑性被认为是癌细胞的一个标志性特征，使其能够在肿瘤进展过程中适应微环境变化。脂质代谢失调在促进肿瘤发生中起着关键作用。致癌信号通路，如PI3K/AKT/mTOR、JAK/STAT、Hippo和NF-κB，与脂质代谢相互作用，共同驱动肿瘤进展。此外，肿瘤微环境中脂质信号传导的改变会导致免疫功能失调，从而加剧肿瘤发生。本综述探讨了脂质代谢在肿瘤起始、侵袭、转移以及癌症干细胞维持中的作用。我们重点分析了脂质代谢中的调控网络，以揭示癌症诊断、预后和治疗的新途径。

原文链接：

Targeting Dysregulated Lipid Metabolism in Cancer with Pharmacological Inhibitors