文章：

儿童急性白血病幸存者中胰岛素样生长因子-1与骨密度的关联性研究

Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute Leukemia

原文发布日期：27 March 2024

DOI: 10.3390/cancers16071296

类型: Article

开放获取: 是

英文摘要：

In this study, we investigated bone mineral deficits in children who survived childhood acute leukemia and explored the association between the insulin-like growth factor-1 (IGF-1) level and bone mineral density (BMD). This retrospective analysis enrolled 214 patients treated for acute leukemia, measuring various factors including height, weight, body mass index (BMI), and lumbar spine BMD after the end of treatment. The study found an overall prevalence of low BMD in 15% of participants. Notably, IGF-1 levels were significantly different between patients with low BMD and those with normal BMD, and correlation analyses revealed associations of the IGF-1 level and BMI with lumbar spine BMD. Regression analyses further supported this relationship, suggesting that higher IGF-1 levels were associated with a decreased risk of low BMD. The study findings suggest that IGF-1 may serve as a valuable tool for evaluating and predicting osteoporosis in survivors of childhood acute leukemia.

摘要翻译： 

本研究调查了儿童急性白血病幸存者的骨矿物质缺乏情况，并探讨了胰岛素样生长因子-1（IGF-1）水平与骨密度（BMD）之间的关联。这项回顾性分析纳入了214例接受急性白血病治疗的患者，在治疗结束后测量了身高、体重、体重指数（BMI）及腰椎骨密度等多种指标。研究发现，参与者中骨密度偏低的总患病率为15%。值得注意的是，骨密度偏低患者与骨密度正常患者的IGF-1水平存在显著差异，相关性分析显示IGF-1水平和BMI均与腰椎骨密度存在关联。回归分析进一步支持了这一关系，表明较高的IGF-1水平与较低的骨密度偏低风险相关。研究结果表明，IGF-1可作为评估和预测儿童急性白血病幸存者骨质疏松症的重要指标。

原文链接：

Association of Insulin-like Growth Factor-1 with Bone Mineral Density in Survivors of Childhood Acute Leukemia