文章：

卡波西肉瘤患者的电化学疗法：从金标准策略到局部晚期皮肤及皮下病变

Electrochemotherapy in Kaposi’s Sarcoma Patients: From the Gold Standard Strategy to Locally Advanced Cutaneous and Subcutaneous Lesions

原文发布日期：27 March 2024

DOI: 10.3390/cancers16071295

类型: Article

开放获取: 是

英文摘要：

Electrochemotherapy (ECT) is one of the newest therapeutic strategies employed as a medical procedure for skin neoplasms’ treatment, especially for classic Kaposi’s sarcoma (CKS). The aim of this study was to demonstrate ECT clinical response and the local control of CKS disease. The primary endpoint was to value the worth and efficacy of this local therapy in CKS skin lesions’ treatment. In total, 19 CKS patients were enrolled, 14 males and 5 females with median age at diagnosis of 72. Complete response (CR) has been gained in 12 patients after first ECT attempt; meanwhile, 3 and 4 out of 19 patients obtained a partial response (PR), so they underwent a second and third ECT treatment, respectively. Clinical response was evaluated during the entire timeframe of the follow-up, which ranged between 3 months and 4 years with a median of 18 months. The control of CKS skin lesions still represents a challenge for surgeons and oncologists. Nevertheless, according to this and other authors’ recent experiences, ECT could be considered the gold standard strategy for early-stage patients, but at the same time it could be considered as a valid option in controlling Kaposi’s sarcoma locally advanced lesions.

摘要翻译： 

电化学疗法是皮肤肿瘤治疗领域最新的治疗策略之一，尤其适用于经典型卡波西肉瘤的临床治疗。本研究旨在评估电化学疗法对经典型卡波西肉瘤的临床应答及局部控制效果，主要研究终点在于评价该局部疗法治疗经典型卡波西肉瘤皮肤病灶的价值与疗效。研究共纳入19例经典型卡波西肉瘤患者，其中男性14例，女性5例，确诊中位年龄为72岁。首次电化学治疗后，12例患者获得完全缓解；其余7例患者中，3例实现部分缓解并接受二次治疗，4例经二次治疗后仍为部分缓解而接受第三次治疗。在为期3个月至4年（中位随访时间18个月）的全程随访期间持续评估临床应答。目前经典型卡波西肉瘤皮肤病灶的控制仍是外科与肿瘤科医师面临的临床挑战。然而根据本研究及其他学者近期经验，电化学疗法不仅可视为早期患者的金标准治疗方案，同时也可作为局部进展期卡波西肉瘤病灶控制的有效选择。

原文链接：

Electrochemotherapy in Kaposi’s Sarcoma Patients: From the Gold Standard Strategy to Locally Advanced Cutaneous and Subcutaneous Lesions