文章：

影响微波消融区域大小的因素：一项回顾性分析

Factors Impacting Microwave Ablation Zone Sizes: A Retrospective Analysis

原文发布日期：26 March 2024

DOI: 10.3390/cancers16071279

类型: Article

开放获取: 是

英文摘要：

Purpose: Evaluation of the influence of intrinsic and extrinsic conditions on ablation zone volumes (AZV) after microwave ablation (MWA). Methods: Retrospective analysis of 38 MWAs of therapy-naïve liver tumours performed with the NeuWave PR probe. Ablations were performed either in the ‘standard mode’ (65 W, 10 min) or in the ‘surgical mode’ (95 W, 1 min, then 65 W, 10 min). AZV measurements were obtained from contrast-enhanced computed tomography immediately post-ablation. Results: AZVs in the ‘standard mode’ were smaller than predicted by the manufacturer (length 3.6 ± 0.6 cm, 23% below 4.7 cm; width 2.7 ± 0.6, 23% below 3.5 cm). Ablation zone past the tip was limited to 6 mm in 28/32 ablations. Differences in AZV between the ‘surgical mode’ and ‘standard mode’ were not significant (15.6 ± 7.8 mL vs. 13.9 ± 8.8 mL,p= 0.6). AZVs were significantly larger in case of hepatocellular carcinomas (HCCs) (n= 19) compared to metastasis (n= 19; 17.8 ± 9.9 mL vs. 10.1 ± 5.1 mL,p= 0.01) and in non-perivascular tumour location (n= 14) compared to perivascular location (n= 24, 18.7 ± 10.4 mL vs. 11.7 ± 6.1 mL,p= 0.012), with both factors remaining significant in two-way analysis of variance (HCC vs. metastasis:p= 0.02; perivascular vs. non-perivascular tumour location:p= 0.044). Conclusion: Larger AZVs can be expected in cases of HCCs compared with metastases and in non-perivascular locations. Using the ‘surgical mode’ does not increase AZV significantly.

摘要翻译： 

目的：评估内源性及外源性因素对微波消融术后消融区体积的影响。方法：回顾性分析38例采用NeuWave PR探针治疗初治肝肿瘤的微波消融病例。消融模式分为"标准模式"（65W，10分钟）与"外科模式"（95W，1分钟后转为65W，10分钟）。消融区体积通过术后即刻增强计算机断层扫描进行测量。结果："标准模式"下消融区体积小于制造商预测值（长径3.6±0.6cm，较预测值4.7cm低23%；宽径2.7±0.6cm，较预测值3.5cm低23%）。32例消融中28例的消融区尖端延伸距离不超过6mm。"外科模式"与"标准模式"的消融区体积无显著差异（15.6±7.8 mL vs. 13.9±8.8 mL，p=0.6）。肝细胞癌组（n=19）消融区体积显著大于转移瘤组（n=19）（17.8±9.9 mL vs. 10.1±5.1 mL，p=0.01）；非血管旁肿瘤组（n=14）显著大于血管旁肿瘤组（n=24）（18.7±10.4 mL vs. 11.7±6.1 mL，p=0.012）。双因素方差分析显示肿瘤类型（p=0.02）与解剖位置（p=0.044）均为独立影响因素。结论：相较于转移瘤，肝细胞癌可获得更大消融区体积；非血管旁位置的消融效果优于血管旁位置。"外科模式"未能显著增加消融区体积。

原文链接：

Factors Impacting Microwave Ablation Zone Sizes: A Retrospective Analysis