The use of blue light cystoscopy (BLC) has been shown to improve bladder tumor detection. However, data demonstrating the efficacy of BLC across different races are limited. Herein, we aim to evaluate heterogeneity in the characteristics of BLC for the detection of malignant lesions among various races. Clinicopathologic information was collected from patients enrolled in the multi-institutional Cysview®registry (2014–2021) who underwent transurethral resection or biopsy of bladder tumors. Outcome variables included sensitivity and negative and positive predictive values of BLC and white light cystoscopy (WLC) for the detection of malignant lesions among various races. Overall, 2379 separate lesions/tumors were identified from 1292 patients, of whom 1095 (85%) were Caucasian, 96 (7%) were African American, 51 (4%) were Asian, and 50 (4%) were Hispanic. The sensitivity of BLC was higher than that of WLC in the total cohort, as well as in the Caucasian and Asian subgroups. The addition of BLC to WLC increased the detection rate by 10% for any malignant lesion in the total cohort, with the greatest increase in Asian patients (18%). Additionally, the positive predictive value of BLC was highest in Asian patients (94%), while Hispanic patients had the highest negative predictive value (86%). Our study showed that regardless of race, BLC increases the detection of bladder cancer when combined with WLC.
蓝光膀胱镜（BLC）已被证实可提高膀胱肿瘤检出率，但证明其在不同种族间有效性的数据有限。本研究旨在评估BLC检测恶性病变特征在不同种族间的异质性。我们从多中心Cysview®注册数据库（2014-2021年）中收集了接受经尿道膀胱肿瘤切除或活检患者的临床病理信息。结局变量包括BLC与白光膀胱镜（WLC）在不同种族中检测恶性病变的敏感性、阴性预测值及阳性预测值。研究共纳入1292例患者的2379个独立病灶/肿瘤，其中高加索人种1095例（85%）、非洲裔96例（7%）、亚洲裔51例（4%）、西班牙裔50例（4%）。在总体队列及高加索人种、亚洲裔亚组中，BLC的敏感性均高于WLC。在总体队列中，BLC联合WLC使所有恶性病变检出率提升10%，其中亚洲裔患者提升幅度最大（18%）。此外，BLC的阳性预测值在亚洲裔患者中最高（94%），而西班牙裔患者的阴性预测值最高（86%）。本研究表明，无论种族如何，BLC联合WLC均可提高膀胱癌检出率。
肿瘤(癌症)患者之家