(1) Background: The relationship between periodontitis and systemic pathologies continues to grow. Recently, the presence of periodontal pathogens has been linked to an increased risk of pancreatic cancer (PC) and its mortality. Thus, a systematic review is needed to identify whether an association between the two diseases can be established. The objective of this review is to elucidate the mechanisms responsible for this association. (2) Methods: A systematic review was carried out using three databases (PubMed, Embase and Scopus) with the following keywords “Periodontitis AND pancreatic cancer”. A total of 653 articles were retrieved; before selection and screening, the inclusion and exclusion criteria were defined, resulting in a total of 13 articles being included in the review. (3) Results: The increase in low-grade systemic inflammation, pH changes, and the cytotoxicity of certain periodontopathogenic bacteria were found in the scientific literature reviewed as mechanisms linking periodontitis with the risk of PC. (4) Conclusions: Through this systematic review, we have seen how periodontitis can be related to PC and how it worsens its prognosis. Knowing the behavior of periodontopathogenic bacteria and the influence they have on our immune and inflammatory system may help to achieve an interdisciplinary approach to both pathologies.
(1) 背景：牙周炎与全身性疾病之间的关联日益受到关注。近期研究表明，牙周病原体的存在与胰腺癌发病风险及其死亡率升高相关。因此，有必要通过系统综述明确这两种疾病之间是否存在关联。本综述旨在阐明导致该关联的潜在机制。(2) 方法：通过PubMed、Embase和Scopus三个数据库，以"牙周炎与胰腺癌"为关键词进行系统文献检索，共获得653篇文献。在筛选前明确纳入与排除标准，最终有13篇文献被纳入本综述。(3) 结果：现有科学文献表明，低度全身性炎症加剧、pH值改变以及特定牙周致病菌的细胞毒性作用，是牙周炎与胰腺癌风险相关联的潜在机制。(4) 结论：本系统综述揭示了牙周炎与胰腺癌的关联性及其对预后的不良影响。深入了解牙周致病菌的特性及其对免疫和炎症系统的影响，将有助于建立针对这两种疾病的跨学科诊疗策略。
Could Periodontitis Increase the Risk of Suffering from Pancreatic Cancer?—A Systematic Review
肿瘤(癌症)患者之家