文章：

肿瘤浸润淋巴细胞水平与剪切波弹性成像测得的较低硬度持续相关：其在乳腺癌中的亚型特异性意义分析

Tumor-Infiltrating Lymphocyte Level Consistently Correlates with Lower Stiffness Measured by Shear-Wave Elastography: Subtype-Specific Analysis of Its Implication in Breast Cancer

原文发布日期：22 March 2024

DOI: 10.3390/cancers16071254

类型: Article

开放获取: 是

英文摘要：

Background:We aimed to elucidate the clinical significance of tumor stiffness across breast cancer subtypes and establish its correlation with the tumor-infiltrating lymphocyte (TIL) levels using shear-wave elastography (SWE).Methods:SWE was used to measure tumor stiffness in breast cancer patients from January 2016 to August 2020. The association of tumor stiffness and clinicopathologic parameters, including the TIL levels, was analyzed in three breast cancer subtypes.Results: A total of 803 patients were evaluated. Maximal elasticity (Emax) showed a consistent positive association with an invasive size and the pT stage in all cases, while it negatively correlated with the TIL level. A subgroup-specific analysis revealed that the already known parameters for high stiffness (lymphovascular invasion, lymph node metastasis, Ki67 levels) were significant only in hormone receptor-positive and HER2-negative breast cancer (HR + HER2-BC). In the multivariate logistic regression, an invasive size and low TIL levels were significantly associated with Emaxin HR + HER2-BC and HER2 + BC. In triple-negative breast cancer, only TIL levels were significantly associated with low Emax. Linear regression confirmed a consistent negative correlation between TIL and Emaxin all subtypes.Conclusions: Breast cancer stiffness presents varying clinical implications dependent on the tumor subtype. Elevated stiffness indicates a more aggressive tumor biology in HR + HER2-BC, but is less significant in other subtypes. High TIL levels consistently correlate with lower tumor stiffness across all subtypes.

摘要翻译： 

背景：本研究旨在通过剪切波弹性成像技术，阐明不同乳腺癌亚型中肿瘤硬度的临床意义，并探究其与肿瘤浸润淋巴细胞水平之间的相关性。 方法：对2016年1月至2020年8月期间的乳腺癌患者采用剪切波弹性成像技术测量肿瘤硬度。在三种乳腺癌亚型中，分析肿瘤硬度与临床病理参数（包括肿瘤浸润淋巴细胞水平）的关联性。 结果：共纳入803例患者进行分析。在所有病例中，最大弹性值均与浸润性病灶大小及病理T分期呈持续正相关，而与肿瘤浸润淋巴细胞水平呈负相关。亚组特异性分析显示，已知的高硬度相关参数（淋巴血管侵犯、淋巴结转移、Ki67水平）仅在激素受体阳性/HER2阴性乳腺癌中具有显著意义。在多因素逻辑回归分析中，浸润性病灶大小和低肿瘤浸润淋巴细胞水平与激素受体阳性/HER2阴性乳腺癌及HER2阳性乳腺癌的最大弹性值显著相关。在三阴性乳腺癌中，仅肿瘤浸润淋巴细胞水平与低最大弹性值显著相关。线性回归分析证实所有亚型中肿瘤浸润淋巴细胞水平与最大弹性值均存在一致的负相关关系。 结论：乳腺癌硬度在不同肿瘤亚型中呈现差异化的临床意义。在激素受体阳性/HER2阴性乳腺癌中，硬度升高提示更具侵袭性的肿瘤生物学特性，但在其他亚型中这一关联较弱。所有亚型中，高肿瘤浸润淋巴细胞水平均与较低的肿瘤硬度存在稳定相关性。

原文链接：

Tumor-Infiltrating Lymphocyte Level Consistently Correlates with Lower Stiffness Measured by Shear-Wave Elastography: Subtype-Specific Analysis of Its Implication in Breast Cancer