Metastasis is a key determinant of cancer progression, influenced significantly by genetic mechanisms. RRP1B, primarily a nucleolar protein, emerges as a suppressor of metastasis, forming alliances with various cellular components and modulating gene expression. This study investigates the involvement of the ribosomal RNA processing 1 homolog B (RRP1B) gene in metastasis regulation in cervical cancer. Through a comprehensive analysis of 172 cervical cancer patients, we evaluated fiveRRP1Bsingle nucleotide polymorphisms (SNPs) (rs2838342, rs7276633, rs2051407, rs9306160, and rs762400) for their associations with clinicopathological features and survival outcomes. Significant associations were observed between specific genetic variants and clinicopathological parameters. Notably, the A allele of rs2838342 was associated with reduced odds of advanced tumor size, worse prognosis, and, preliminarily, distant metastasis, while the T allele of rs7276633 correlated with a decreased risk of higher tumor size and worse prognosis. Additionally, the C allele of rs2051407 demonstrated protective effects against larger tumors, metastasis, and adverse prognosis. The rs9306160 C allele exhibited a protective effect against metastasis. The rs762400 G allele was significant for reduced tumor size and metastasis risk. Furthermore, the rs2838342 A allele, rs7276633 T allele, rs2051407 C allele, and rs762400 G allele were associated with improved overall survival, demonstrating their potential significance in predicting prognoses in cervical cancer. Linkage disequilibrium and haplotypes analysis enabled us to evaluate the collective effect of the analyzed SNPs, which was in line with the results of allelic models. Our findings underscore the clinical relevance ofRRP1BSNPs as prognostic markers in cervical cancer, shedding light on the intricate interplay between genetic factors and disease-progression dynamics. This research provides critical insights for future investigations and underscores the importance of incorporatingRRP1BSNP detection into prognostic-assessment tools for accurate prediction of disease outcomes in cervical cancer.
转移是癌症进展的关键决定因素，显著受遗传机制影响。RRP1B主要作为一种核仁蛋白，被发现具有抑制转移的作用，能与多种细胞成分结合并调控基因表达。本研究探讨了核糖体RNA加工1同源物B（RRP1B）基因在宫颈癌转移调控中的作用。通过对172例宫颈癌患者的综合分析，我们评估了五个RRP1B单核苷酸多态性（SNPs）（rs2838342、rs7276633、rs2051407、rs9306160和rs762400）与临床病理特征及生存结局的关联。研究发现特定遗传变异与临床病理参数存在显著关联。值得注意的是，rs2838342的A等位基因与较小肿瘤体积、较差预后以及初步发现的远处转移风险降低相关；而rs7276633的T等位基因则与较低的大肿瘤风险和较差预后相关。此外，rs2051407的C等位基因对较大肿瘤、转移及不良预后显示出保护作用；rs9306160的C等位基因对转移具有保护效应；rs762400的G等位基因则与减小肿瘤体积和降低转移风险显著相关。进一步分析显示，rs2838342 A等位基因、rs7276633 T等位基因、rs2051407 C等位基因和rs762400 G等位基因均与改善的总生存期相关，表明其在预测宫颈癌预后方面具有潜在价值。通过连锁不平衡和单倍型分析，我们评估了这些SNPs的联合效应，其结果与等位基因模型的分析结论一致。本研究结果强调了RRP1B SNPs作为宫颈癌预后标志物的临床意义，揭示了遗传因素与疾病进展动态之间复杂的相互作用。该研究为未来探索提供了重要见解，并凸显了将RRP1B SNP检测纳入预后评估工具对准确预测宫颈癌疾病转归的重要性。
Impact ofRRP1BVariants on the Phenotype, Progression, and Metastasis of Cervical Cancer
肿瘤(癌症)患者之家