The management of patients undergoing HSCT requires a multipurpose central venous catheter. Peripheral catheters (PCs), such as peripherally inserted central catheters (PICCs) and MidLine catheters (MLCs), appear to be adequate vascular catheters to be used for stem cell infusion, although their utilization in this indication is not yet common. We analyzed the infectious complications such as blood stream infection (BSI), febrile neutropenia (FN) and central line-associated bloodstream infection (CLBSI) in patients undergoing stem cell infusion through PC and conventionally inserted central catchers (CICCs), and evaluated their impacts on transplantation outcomes. Our results reveal no statistically significant differences between different types of catheter in terms of FN, BSI and CLABSI. Moreover, transplantation outcomes were comparable between the groups. Interestingly, according to our data, there were no differences in terms of abovementioned infectious complications between individuals who received antibiotic prophylaxis and those who did not. Our study has shown that infection complications are independent of the intravenous device and antibiotic prophylaxis. Considering that PCs are not associated with life-threatening complications, they should be considered more frequently in the stem cell transplantation setting.
造血干细胞移植患者的管理需要多功能中心静脉导管。外周导管（如经外周静脉置入的中心静脉导管和中线导管）虽在此类适应症中应用尚不普遍，但可作为干细胞输注的适宜血管通路装置。本研究通过对比分析经外周导管与传统中心静脉导管进行干细胞输注患者的血流感染、发热性中性粒细胞减少症及导管相关血流感染等感染性并发症，评估其对移植结局的影响。结果显示不同导管类型在发热性中性粒细胞减少症、血流感染及导管相关血流感染发生率方面无统计学显著差异，且两组移植结局具有可比性。值得注意的是，根据本研究数据，预防性使用抗生素与未使用者在上述感染性并发症方面未见差异。研究表明感染并发症的发生与静脉装置类型及抗生素预防措施无关。鉴于外周导管不伴随危及生命的并发症风险，在干细胞移植临床实践中应更积极地考虑其应用价值。
肿瘤(癌症)患者之家