(1) Background: Health-related quality of life (HRQoL) gains importance as novel treatment options for individuals with esophagogastric tumors to improve long-term survival. Impaired HRQoL has been shown to be a predictor of overall survival. Sarcopenia is a known prognostic factor for postoperative complications. As the regular control of sarcopenia through CT scans might not always be possible and HRQoL and nutritional scores are easier to obtain, this study aimed to assess the relationship between nutritional scores, HRQoL and skeletal muscle mass in patients undergoing chemotherapy for cancers of the upper gastrointestinal tract. (2) Methods: Eighty patients presenting with tumors of the upper GI tract were included and asked to fill out the standardized HRQoL questionnaire, EORTC’s QLQ-C30. Nutritional status was assessed using the MNA, MUST and NRS 2002 scores. Sarcopenia was determined semi-automatically based on the skeletal muscle index at the L3 vertebrae level in staging CT scans. (3) Results: In chemo-naïve patients, HRQoL summary scores correlated significantly with nutritional scores and SMI. SMI and HRQoL prior to neoadjuvant therapy correlated significantly with SMI after treatment. (4) Conclusions: HRQoL is a helpful tool for assessing patients’ overall constitution. The correlation of HRQoL summary scores and SMI might allow for a rough assessment of skeletal muscle status through HRQoL assessment in chemo-naïve patients.
（1）背景：随着食管胃肿瘤患者新治疗方案的出现以改善长期生存，健康相关生活质量（HRQoL）的重要性日益凸显。已有研究表明，HRQoL受损是总体生存期的预测因子。肌肉减少症是术后并发症的已知预后因素。由于通过CT扫描定期监测肌肉减少症可能并不总是可行，而HRQoL和营养评分更易获取，本研究旨在评估上消化道肿瘤化疗患者的营养评分、HRQoL与骨骼肌质量之间的关系。（2）方法：研究纳入80例上消化道肿瘤患者，要求其填写标准化的HRQoL问卷——欧洲癌症研究与治疗组织生活质量核心量表（EORTC QLQ-C30）。营养状况采用微型营养评估（MNA）、营养不良通用筛查工具（MUST）及营养风险筛查2002（NRS 2002）进行评估。肌肉减少症通过分期CT扫描中第三腰椎水平的骨骼肌指数进行半自动测定。（3）结果：在初治化疗患者中，HRQoL综合评分与营养评分及骨骼肌指数显著相关。新辅助治疗前的骨骼肌指数和HRQoL与治疗后骨骼肌指数显著相关。（4）结论：HRQoL是评估患者整体状况的有效工具。HRQoL综合评分与骨骼肌指数的相关性提示，在初治化疗患者中可通过HRQoL评估对骨骼肌状态进行粗略判断。
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