(1) Background: Skin cancer is the most common cancer in transplant recipients. Timely and regular screening may reduce advanced disease. The study aimed to determine referral rates to screening, the incidence, and risk factors of skin cancer in a Danish liver transplant recipient cohort. (2) Methods: All first-time liver transplant recipients, >18 years old, attending outpatient care between January 2018 and December 2021 were included. The referral rates and incidence of skin cancer/preneoplastic lesions were calculated. Risk factors were assessed using Cox regression analyses. (3) Results: Of the 246 included recipients, 219 (89.0%) were referred to screening, and 102 skin cancer/preneoplastic lesions were diagnosed in 32 (15.6%) recipients. The IR of any skin cancer/preneoplastic lesion was 103.2 per 1000 person-years. BCC was the most frequent skin cancer followed by SCC, IR: 51.3 vs. 27.1 per 1000 person-years, respectively. No cases of MM were observed. The IR of actinic keratosis and Bowen’s Disease were 48.1 vs. 13.2 per 1000 person-years, respectively. Time since transplantation was independently associated with skin cancer/preneoplastic lesions, HR (95%CI) 2.81 (1.64–4.80). (4) Conclusions: The study determined the incidence and risk factors of skin cancer/preneoplastic lesions in liver transplant recipients enrolled in a screening program, while demonstrating a high screening referral rate.
(1) 背景：皮肤癌是移植受者中最常见的恶性肿瘤。及时且规律的筛查可降低晚期疾病发生率。本研究旨在确定丹麦肝移植受者队列中皮肤癌筛查转诊率、发病率及相关危险因素。(2) 方法：纳入2018年1月至2021年12月期间接受门诊随访的所有首次肝移植受者（年龄>18岁）。计算皮肤癌/癌前病变的转诊率与发病率，并采用Cox回归模型评估危险因素。(3) 结果：在246例受者中，219例（89.0%）获得筛查转诊，其中32例（15.6%）共确诊102处皮肤癌/癌前病变。皮肤癌/癌前病变总发病密度为103.2例/1000人年。基底细胞癌（BCC）是最常见的皮肤癌类型（51.3例/1000人年），其次为鳞状细胞癌（SCC）（27.1例/1000人年），未观察到黑色素瘤（MM）病例。光化性角化病与鲍恩病的发病密度分别为48.1例/1000人年与13.2例/1000人年。移植后时间与皮肤癌/癌前病变独立相关，风险比HR（95%CI）为2.81（1.64-4.80）。(4) 结论：本研究明确了参与筛查项目的肝移植受者皮肤癌/癌前病变的发病率及危险因素，同时证实了该群体具有较高的筛查转诊率。
Early Results of a Screening Program for Skin Cancer in Liver Transplant Recipients: A Cohort Study
肿瘤(癌症)患者之家