The glycoprotein CD44, with its many isoforms and variations in carbohydrate patterning, participates in a diverse set of cellular functions. This fact leads to the protein playing a role in many normal and pathologic cellular processes including a role in cancer progression and metastasis. These same facts make CD44 a strong therapeutic target in many cancer types, including bladder cancer.
糖蛋白CD44因其多种亚型及碳水化合物模式的多样性,参与了广泛的细胞功能。这一特性使其在众多正常及病理细胞过程中发挥作用,包括癌症的进展与转移。正是基于这些特性,CD44成为包括膀胱癌在内的多种癌症类型的重要治疗靶点。