Endometrial carcinoma stands as the most prevalent gynecological cancer and the fourth most common cancer affecting women. The incidence of endometrial cancer has been steadily increasing over the past decade, posing a significant threat to public health. The early detection of its precancers remains a critical and evolving concern to reduce mortality associated with endometrial carcinoma. In the last decade, our understanding of endometrial carcinoma and its precancers has advanced through systematic investigations into the molecular genetics of endometrial carcinoma and its precancers. In this review, we focus on advances in precancers associated with the endometrioid subtype, by far the most common histologic variant of endometrial adenocarcinoma. Recent investigations have led to the identification of new biomarkers, and the proposed incorporation of these biomarkers or biomarker panels into the diagnostic framework of endometrial carcinoma precancers. Here, we review these recent advances and their relevance to the histopathologic diagnosis of endometrial carcinoma precancers.
子宫内膜癌是最常见的妇科恶性肿瘤，也是女性第四大常见癌症。过去十年间，子宫内膜癌发病率持续上升，对公共卫生构成重大威胁。早期发现其癌前病变仍是降低子宫内膜癌相关死亡率的关键且不断发展的课题。近十年来，通过对子宫内膜癌及其癌前病变分子遗传学的系统性研究，我们对其认识取得了显著进展。本综述重点关注子宫内膜样亚型相关癌前病变的研究进展，该亚型是目前子宫内膜腺癌中最常见的组织学变异。最新研究已鉴定出新型生物标志物，并建议将这些标志物或标志物组合纳入子宫内膜癌前病变的诊断体系。本文系统回顾了这些最新进展及其与子宫内膜癌前病变组织病理学诊断的相关性。
肿瘤(癌症)患者之家