Hyperthermia (HT) is an anti-cancer therapy commonly used with radio and chemotherapies based on applying heat (39–45 °C) to inhibit tumor growth. However, controlling heat towards tumors and not normal tissues is challenging. Therefore, nanoparticles (NPs) are used in HT to apply heat only to tumor tissues to induce DNA damage and the expression of heat shock proteins, which eventually result in apoptosis. The aim of this review article is to summarize recent advancements in HT with the use of magnetic NPs to locally increase temperature and promote cell death. In addition, the recent development of nanocarriers as NP-based drug delivery systems is discussed. Finally, the efficacy of HT combined with chemotherapy, radiotherapy, gene therapy, photothermal therapy, and immunotherapy is explored.
热疗（HT）是一种常与放疗和化疗联合应用的抗癌疗法，其原理是通过施加热量（39–45°C）抑制肿瘤生长。然而，如何将热量精准作用于肿瘤组织而不损伤正常组织仍具挑战性。因此，纳米颗粒（NPs）被应用于热疗中，以实现仅对肿瘤组织进行加热，从而诱导DNA损伤和热休克蛋白表达，最终引发细胞凋亡。本文旨在综述利用磁性纳米颗粒实现局部升温并促进细胞死亡的热疗技术最新进展，同时探讨纳米载体作为基于纳米颗粒的药物递送系统的最新发展。最后，本文还探究了热疗与化疗、放疗、基因治疗、光热疗法及免疫疗法联合应用的疗效。
肿瘤(癌症)患者之家