Background: active surveillance (AS) is a suitable strategy for patients with prostate cancer (PCa). Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging is an established tool used to assess PCa. The aim of this review was to evaluate the role of PSMA imaging to guide correct risk-based classification and the AS approach in PCa patients. Methods: The Scopus, Embase, Web of Science, Cochrane Library, and PubMed/MEDLINE databases were screened to find relevant published articles. Results: 1774 articles were revealed with the literature search. A total of 1764 articles were excluded after applying exclusion criteria (data not within the field of interest, preclinical papers, conference proceedings, reviews, or editorials). Ten studies were finally included in the review, revealing that PSMA PET could have the ability to guide risk-based classification of PCa and the choice of AS, and to guide the execution of biopsies for the research of high-grade PCa, therefore precluding AS. Conclusion: this systematic review underlined a possible role of PSMA PET imaging in patients with PCa by correctly re-classifying them on the basis of their risk and guiding AS.
背景：主动监测（AS）是前列腺癌（PCa）患者的适宜策略。前列腺特异性膜抗原（PSMA）正电子发射断层扫描（PET）成像是评估PCa的成熟工具。本综述旨在评估PSMA成像在指导PCa患者正确风险分层及AS策略选择中的作用。方法：系统检索Scopus、Embase、Web of Science、Cochrane Library及PubMed/MEDLINE数据库以获取相关文献。结果：文献检索共发现1774篇文献，经排除标准（非相关领域数据、临床前研究、会议摘要、综述或社论）筛选后共排除1764篇。最终纳入10项研究，结果表明PSMA PET能够指导PCa的风险分层与AS策略选择，并引导针对高级别PCa的活检实施，从而避免不适宜的AS。结论：本系统综述揭示了PSMA PET成像在PCa患者中可能发挥的重要作用，即通过精准风险再分层指导AS临床决策。
肿瘤(癌症)患者之家