Background: Upper tract urothelial carcinoma (UTUC) is a rare disease with a potentially dismal prognosis. We systematically compared international guidelines on UTUC to analyze similitudes and differences among them. Methods: We conducted a search on MEDLINE/PubMed for guidelines related to UTUC from 2010 to the present. In addition, we manually explored the websites of urological and oncological societies and journals to identify pertinent guidelines. We also assessed recommendations from the International Bladder Cancer Network, the Canadian Urological Association, the European Society for Medical Oncology, and the International Consultation on Bladder Cancer, considering their expertise and experience in the field. Results: Among all the sources, only the American Urologist Association (AUA), European Association of Urology (EAU), and the National Comprehensive Cancer Network (NCCN) guidelines specifically report data on diagnosis, treatment, and follow-up of UTUC. Current analysis reveals several differences between all three sources on diagnostic work-up, patient management, and follow-up. Among all, AUA and EAU guidelines show more detailed indications. Conclusions: Despite the growing incidence of UTUC, only AUA, EAU, and NCCN guidelines deal with this cancer. Our research depicted high variability in reporting recommendations and opinions. In this regard, we encourage further higher-quality research to gain evidence creating higher grade consensus between guidelines.
背景：上尿路尿路上皮癌（UTUC）是一种罕见疾病，预后可能较差。我们系统比较了国际上关于UTUC的指南，以分析其间的异同。方法：我们在MEDLINE/PubMed上检索了2010年至今与UTUC相关的指南。此外，我们手动检索了泌尿外科和肿瘤学会及期刊的网站，以确定相关指南。我们还评估了国际膀胱癌网络、加拿大泌尿外科协会、欧洲肿瘤内科学会和国际膀胱癌咨询会议的建议，考虑了它们在该领域的专业知识和经验。结果：在所有来源中，只有美国泌尿外科协会（AUA）、欧洲泌尿外科协会（EAU）和国家综合癌症网络（NCCN）的指南专门报告了UTUC的诊断、治疗和随访数据。当前分析显示，这三者在诊断检查、患者管理和随访方面存在若干差异。其中，AUA和EAU指南提供了更详细的指导。结论：尽管UTUC的发病率不断上升，但只有AUA、EAU和NCCN的指南涉及此癌症。我们的研究揭示了在报告建议和意见方面存在高度变异性。在这方面，我们鼓励进行更高质量的研究，以获得证据，从而在指南之间建立更高程度的共识。
肿瘤(癌症)患者之家