文章：

肺癌炎性肿瘤微环境中的旁分泌调控与免疫系统通路：对肿瘤发生机制及免疫治疗策略的启示

Paracrine Regulation and Immune System Pathways in the Inflammatory Tumor Microenvironment of Lung Cancer: Insights into Oncogenesis and Immunotherapeutic Strategies

原文发布日期：10 March 2024

DOI: 10.3390/cancers16061113

类型: Article

开放获取: 是

英文摘要：

The intricate interplay between inflammatory processes and the tumor microenvironment (TME) in lung cancer has garnered increasing attention due to its implications for both oncogenesis and therapeutic strategies. In this review, we explore recent advances in understanding the paracrine regulation and immune system pathways within the inflammatory TME of lung cancer. We delve into the molecular mechanisms underpinning oncogenesis, highlighting the role of immune cell populations, cancer-associated fibroblasts, and endothelial cells, as well as their interactions through immune system pathways regulated in a paracrine pattern. Additionally, we discuss emerging immunotherapeutic strategies with a specific focus on the potential of leveraging the inflammatory TME through these pathways to enhance treatment efficacy in lung cancer.

摘要翻译： 

炎症过程与肺癌肿瘤微环境（TME）之间复杂的相互作用，因其对肿瘤发生和治疗策略的重要意义而日益受到关注。本文综述了近期在理解肺癌炎症性肿瘤微环境中旁分泌调控与免疫系统通路方面的研究进展。我们深入探讨了肿瘤发生的分子机制，重点阐述了免疫细胞群、癌症相关成纤维细胞及内皮细胞的作用，以及它们通过旁分泌模式调控的免疫系统通路所介导的相互作用。此外，本文还讨论了新兴的免疫治疗策略，特别关注如何通过这些通路利用炎症性肿瘤微环境来提升肺癌治疗效果。

原文链接：

Paracrine Regulation and Immune System Pathways in the Inflammatory Tumor Microenvironment of Lung Cancer: Insights into Oncogenesis and Immunotherapeutic Strategies