Chalcones are a type of natural flavonoid compound that have been found to possess promising anticancer properties. Studies have shown that chalcones can inhibit the growth and proliferation of cancer cells, induce apoptosis, and suppress tumor angiogenesis. In addition to their potential therapeutic applications, chalcones have also been studied for their chemopreventive effects, which involve reducing the risk of cancer development in healthy individuals. Overall, the anticancer properties of chalcones make them a promising area of research for developing new cancer treatments and preventative strategies. This review aims to provide a thorough overview of the central studies reported in the literature concerning cancer prevention and the treatment of chalcones. Although chalcones target many different mechanisms, the STAT and NF-κB signaling pathways are the ones this review will focus on, highlighting the existing crosstalk between these two pathways and considering the potential therapeutic opportunities for chalcone combinations.
查尔酮是一类天然黄酮类化合物，已被发现具有显著的抗癌特性。研究表明，查尔酮能够抑制癌细胞的生长与增殖，诱导细胞凋亡，并抑制肿瘤血管生成。除了潜在的治疗应用外，查尔酮的化学预防作用也受到广泛研究，即降低健康个体患癌风险。总体而言，查尔酮的抗癌特性使其成为开发新型癌症治疗和预防策略的重要研究方向。本综述旨在全面梳理文献中关于查尔酮在癌症预防与治疗方面的核心研究。尽管查尔酮作用于多种不同机制，但本文将重点关注STAT和NF-κB信号通路，阐明这两条通路间存在的交互作用，并探讨查尔酮联合治疗的潜在治疗前景。
肿瘤(癌症)患者之家