文章：

胶质母细胞瘤的脂质组学特征：癌症研究中的前沿展望

The Lipidomic Signature of Glioblastoma: A Promising Frontier in Cancer Research

原文发布日期：8 March 2024

DOI: 10.3390/cancers16061089

类型: Article

开放获取: 是

英文摘要：

Glioblastoma is the most aggressive primary brain malignancy in adults, and has a survival duration of approximately 15 months. First line treatment involves surgical resection, chemotherapy, and radiation, but despite the multi-pronged approach and advances in cancer research, glioblastoma remains devastating with a high mortality rate. Lipidomics is an emerging discipline that studies lipid pathways and characteristics, and is a promising field to understand biochemical mechanisms. In glioblastoma, disrupted lipid homeostasis has been reported in the literature. A thorough understanding of serum lipidomics may offer ways to better understand glioblastoma biomarkers, prognosis, and treatment options. Here, we review the literature, offering future directions for lipidomics research in glioblastomas.

摘要翻译： 

胶质母细胞瘤是成人中最具侵袭性的原发性脑部恶性肿瘤，其生存期约为15个月。一线治疗包括手术切除、化疗和放疗，但尽管采用多管齐下的方法且癌症研究有所进展，胶质母细胞瘤仍具有高死亡率，预后极差。脂质组学是一门研究脂质代谢途径与特性的新兴学科，为理解生化机制提供了前景广阔的领域。现有文献报道显示，胶质母细胞瘤中存在脂质稳态失调现象。深入理解血清脂质组学可能为探索胶质母细胞瘤的生物标志物、预后判断及治疗方案提供新途径。本文通过文献综述，为胶质母细胞瘤的脂质组学研究指明未来方向。

原文链接：

The Lipidomic Signature of Glioblastoma: A Promising Frontier in Cancer Research