An increased risk of cancer among patients with rheumatoid arthritis (RA) has been reported. However, the risk of RA events among patients with head and neck cancer (HNC) is unknown. Therefore, we investigated the incidence and risk of RA among patients with HNC. This study was based on a cohort dataset. Overall, 2824 individuals without HNC and 706 patients with HNC were selected using propensity score matching. The overall RA event rate was 12.19 for patients with HNC and 7.60 for those without HNC. A significantly increased risk of developing RA was also observed among patients with HNC. The risk of developing RA over time was relatively high within the first year after HNC diagnosis; further, it increased significantly during the follow-up period. Moreover, middle-aged male patients with HNC exhibited an increased risk of developing RA compared with the controls; however, no significant difference was noted among female patients or other age groups. Notably, subgroup analysis according to cancer subtype revealed that only oral cancer survivors had an increased risk of developing RA. These results underscore the importance of vigilant monitoring by clinicians to promptly identify the onset of RA in patients with HNC.
已有研究报道类风湿关节炎（RA）患者患癌风险增加，但头颈癌（HNC）患者发生RA事件的风险尚不明确。为此，本研究探讨了HNC患者中RA的发病率和风险。本研究基于队列数据集，通过倾向评分匹配共纳入2824名非HNC个体及706例HNC患者。HNC患者的总体RA事件发生率为12.19，非HNC人群为7.60。研究发现HNC患者发生RA的风险显著增高，且在确诊HNC后的第一年内随时间推移风险相对较高，随访期间风险进一步显著上升。值得注意的是，与对照组相比，中年男性HNC患者发生RA的风险增加，而女性患者及其他年龄组未见显著差异。根据癌症亚型进行的亚组分析显示，仅口腔癌幸存者发生RA的风险显著升高。这些结果提示临床医生需对HNC患者进行密切监测，以便及时发现RA的发病迹象。
肿瘤(癌症)患者之家