Breast cancer (BrC) is a highly prevalent tumour among women. The high incidence and mortality rate of BrC prompts researchers to search for new markers that will provide information on the possible impact of the therapy on the risk of cancer-related events. This study aimed to investigate whether the level of advanced oxidation protein products (AOPPs) may have a potential impact on disease-free (DFS) and overall survival (OS) in BrC patients with early-stage cancer. Additionally, we tried to assess the relationship between AOPPs and angiogenic parameters. In this study, the pre- and post-treatment AOPP levels were examined in the serum of 70 newly diagnosed BrC women. The receiver operating characteristic curve identified pre- and post-treatment AOPPs to be above 9.37 μM and 10.39 μM, respectively, as the best cut-off values to predict the risk of cancer relapse. Additionally, Kaplan–Meier survival analysis indicated that pre- and post-treatment AOPPs above 9.37 μM and 10.39 μM were associated with significantly poorer OS. The uni- and multivariate Cox regression analysis highlighted that lower levels of pre- and post-treatment AOPPs were associated with a longer duration without relapse or cancer-related death. A positive correlation between concentrations of pre-treatment AOPPs and vascular endothelial growth factor A, and negative correlations with levels of soluble forms of vascular endothelial growth factor receptor type 1 and 2, were found. In conclusion, AOPPs appear to have an important role in predicting cancer-related events and may potentially serve as a simple prognostic marker in clinical practice.
乳腺癌是女性中高发的肿瘤。其高发病率和高死亡率促使研究者寻找新的标志物，以评估治疗对癌症相关事件风险的潜在影响。本研究旨在探讨晚期氧化蛋白产物水平是否可能对早期乳腺癌患者的无病生存期和总生存期产生潜在影响，并尝试评估AOPPs与血管生成参数之间的关系。本研究检测了70例新诊断乳腺癌女性患者血清中治疗前后的AOPP水平。受试者工作特征曲线分析显示，治疗前AOPP水平高于9.37 μM、治疗后高于10.39 μM是预测癌症复发风险的最佳截断值。Kaplan-Meier生存分析表明，治疗前后AOPP水平分别超过9.37 μM和10.39 μM与显著较差的总生存期相关。单因素和多因素Cox回归分析强调，较低的治疗前后AOPP水平与更长的无复发或无癌症相关死亡持续时间相关。研究发现治疗前AOPP浓度与血管内皮生长因子A呈正相关，与可溶性血管内皮生长因子受体1型和2型水平呈负相关。综上所述，AOPPs在预测癌症相关事件中具有重要作用，有望成为临床实践中简便的预后标志物。
肿瘤(癌症)患者之家