Electroporation (EP) is a broadly accepted procedure that, through the application of electric pulses with appropriate amplitudes and waveforms, promotes the delivery of anticancer molecules in various oncology therapies. EP considerably boosts the absorptivity of targeted cells to anticancer molecules of different natures, thus upgrading their effectiveness. Its use in veterinary oncology has been widely explored, and some applications, such as electrochemotherapy (ECT), are currently approved as first-line treatments for several neoplastic conditions. Other applications include irreversible electroporation and EP-based cancer vaccines. In human oncology, EP is still mostly restricted to therapies for cutaneous tumors and the palliation of cutaneous and visceral metastases of malignant tumors. Fields where veterinary experience could help smooth the clinical transition to humans include intraoperative EP, interventional medicine and cancer vaccines. This article recapitulates the state of the art of EP in veterinary and human oncology, recounting the most relevant results to date.
电穿孔（EP）是一种被广泛接受的技术，通过施加具有适当振幅和波形的电脉冲，可促进抗癌分子在各种肿瘤治疗中的递送。电穿孔能显著提高靶细胞对不同性质抗癌分子的吸收能力，从而增强其疗效。该技术在兽医肿瘤学领域已得到广泛探索，其中一些应用如电化学疗法（ECT）目前已获批准作为多种肿瘤疾病的一线治疗方案。其他应用包括不可逆电穿孔和基于电穿孔技术的癌症疫苗。在人类肿瘤学中，电穿孔技术目前仍主要局限于皮肤肿瘤的治疗，以及恶性肿瘤皮肤和内脏转移的姑息治疗。兽医领域的经验可能有助于推动该技术向人类临床应用的过渡，包括术中电穿孔、介入医学和癌症疫苗等领域。本文综述了电穿孔技术在兽医和人类肿瘤学中的最新进展，并总结了迄今为止最重要的研究成果。
Electroporation in Translational Medicine: From Veterinary Experience to Human Oncology
肿瘤(癌症)患者之家