Glutamine, a multifaceted nonessential/conditionally essential amino acid integral to cellular metabolism and immune function, holds pivotal importance in the landscape of cancer therapy. This review delves into the intricate dynamics surrounding both glutamine antagonism strategies and glutamine supplementation within the context of cancer treatment, emphasizing the critical role of glutamine metabolism in cancer progression and therapy. Glutamine antagonism, aiming to disrupt tumor growth by targeting critical metabolic pathways, is challenged by the adaptive nature of cancer cells and the complex metabolic microenvironment, potentially compromising its therapeutic efficacy. In contrast, glutamine supplementation supports immune function, improves gut integrity, alleviates treatment-related toxicities, and improves patient well-being. Moreover, recent studies highlighted its contributions to epigenetic regulation within cancer cells and its potential to bolster anti-cancer immune functions. However, glutamine implementation necessitates careful consideration of potential interactions with ongoing treatment regimens and the delicate equilibrium between supporting normal cellular function and promoting tumorigenesis. By critically assessing the implications of both glutamine antagonism strategies and glutamine supplementation, this review aims to offer comprehensive insights into potential therapeutic strategies targeting glutamine metabolism for effective cancer management.
谷氨酰胺作为一种多功能的非必需/条件必需氨基酸，在细胞代谢和免疫功能中起着核心作用，在癌症治疗领域具有关键意义。本文综述深入探讨了癌症治疗背景下谷氨酰胺拮抗策略与谷氨酰胺补充之间的复杂动态关系，着重强调了谷氨酰胺代谢在癌症进展和治疗中的关键作用。谷氨酰胺拮抗策略旨在通过靶向关键代谢通路来破坏肿瘤生长，但面临癌细胞适应性及复杂代谢微环境的挑战，可能影响其治疗效果。相比之下，谷氨酰胺补充则能支持免疫功能、改善肠道完整性、减轻治疗相关毒性并提升患者生活质量。最新研究还揭示了其对癌细胞表观遗传调控的贡献，以及增强抗癌免疫功能的潜力。然而，实施谷氨酰胺干预需审慎考虑其与现有治疗方案的潜在相互作用，以及在支持正常细胞功能与促进肿瘤发生之间保持微妙平衡。通过批判性评估谷氨酰胺拮抗策略与补充方案的双重意义，本综述旨在为靶向谷氨酰胺代谢的有效癌症治疗策略提供全面见解。
肿瘤(癌症)患者之家