文章：

靶向荧光引导手术的单克隆抗体：在多种实体瘤中的适用性综述

Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors

原文发布日期：4 March 2024

DOI: 10.3390/cancers16051045

类型: Article

开放获取: 是

英文摘要：

This study aims to review the status of the clinical use of monoclonal antibodies (mAbs) that have completed or are in ongoing clinical trials for targeted fluorescence-guided surgery (T-FGS) for the intraoperative identification of the tumor margins of extra-hematological solid tumors. For each of them, the targeted antigen, the mAb generic/commercial name and format, and clinical indications are presented, together with utility, doses, and the timing of administration. Based on the current scientific evidence in humans, the top three mAbs that could be prepared in a GMP-compliant bank ready to be delivered for surgical purposes are proposed to speed up the translation to the operating room and produce a few readily available “off-the-shelf” injectable fluorescent probes for safer and more effective solid tumor resection.

摘要翻译： 

本研究旨在综述已完成或正在进行临床试验的单克隆抗体（mAbs）在靶向荧光引导手术（T-FGS）中用于术中识别非血液系统实体瘤肿瘤边界的临床应用现状。针对每种抗体，详细介绍了其靶向抗原、单克隆抗体的通用名/商品名及结构形式、临床适应症，同时涵盖其应用价值、使用剂量及给药时机。基于当前人体科学证据，本研究提出三种最有可能符合GMP标准、可制备成即用型储备库的单克隆抗体，以加速其向手术室应用的转化，从而提供数种易于获取的“即用型”可注射荧光探针，以实现更安全、更有效的实体瘤切除。

原文链接：

Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors