Introduction: Overweight and a lack of physical activity not only increase the risk of recurrence in breast cancer patients but also negatively impact overall and long-term survival, as well as quality of life. The results presented here are the first real-world data from the DiGA PINK! Coach examining the physical activity and BMI of app users. Based on the literature, an approximate weight gain of 10% over 6 months and a decrease in physical activity can be expected. The purpose of this study is to retrospectively investigate the effects of the PINK! Coach in a real-world setting on patients’ BMI and physical activity level during acute therapies. such as chemotherapy (CHT) and antihormone therapy (AHT). Material and Methods: The PINK! Coach app accompanies breast cancer patients during and after acute therapy to bring about a sustainable lifestyle change. The patients are encouraged to establish a healthy diet, become physically active, and make informed decisions. In this study, real-world data from the app were analyzed over 6 months from baseline to T1 (after 12 weeks) and T2 (after 24 weeks). The patients were under acute therapy or in follow-up care receiving either CHT or AHT. Results: The analyzed data indicate that all patients were able to maintain a consistent BMI over 6 months independent of pre-defined subgroups such as AHT, CHT, or BMI subgroups. In the subgroup of patients undergoing AHT, overweight patients were even able to significantly reduce their BMI by 1-score-point over 6 months (p< 0.01). The subgroup of patients undergoing CHT also showed an significant overall reduction in BMI (p= 0.01). All patients were also able to significantly increase their daily step count as well as their physical activity minutes per day. After the first 12 weeks, 41.4% of patients experienced weight gain, 33.4% were able to maintain their weight, and 24.2% reduced their weight. Conclusion: The presented data provides intriguing insights into the users of the PINK! Coach app and the impact of this usage in regards to BMI and physical activity. At the current time, there are only a few effective concepts for encouraging all breast cancer patients to engage in moderate physical activity and reduce body weight. Often, these concepts apply to selected patient groups. The data presented here include all age groups, tumor stages, and therapies, providing an initial insight into a comprehensive approach. Data over an even longer period would be one way to better contextualize the results in current research.
引言：超重与缺乏体力活动不仅会增加乳腺癌患者的复发风险，还会对总体生存率、长期生存率及生活质量产生负面影响。本文呈现的数据是来自DiGA PINK! Coach应用程序的首个真实世界研究结果，旨在分析应用使用者的体力活动水平与身体质量指数（BMI）。根据文献报道，患者在6个月内可能出现约10%的体重增长及体力活动水平下降。本研究旨在回顾性探讨PINK! Coach在真实临床环境中对接受化疗（CHT）和抗激素治疗（AHT）等急性治疗期间患者BMI及体力活动水平的影响。 材料与方法：PINK! Coach应用程序在乳腺癌患者急性治疗期间及治疗后提供全程陪伴，旨在实现可持续的生活方式转变。该应用鼓励患者建立健康饮食习惯、积极参与体力活动并做出知情决策。本研究分析了应用程序采集的真实世界数据，时间跨度为基线至T1（12周后）和T2（24周后）共6个月。研究对象为正在接受CHT或AHT急性治疗或处于随访护理阶段的患者。 结果：数据分析表明，所有患者在6个月内均能保持稳定的BMI水平，这一现象不受预设亚组（包括AHT、CHT或BMI亚组）的影响。在接受AHT治疗的超重患者亚组中，BMI在6个月内显著降低1个评分点（p<0.01）。接受CHT治疗的患者亚组同样显示出BMI的显著整体下降（p=0.01）。所有患者的日均步数及每日体力活动时长均实现显著提升。治疗前12周后，41.4%的患者出现体重增加，33.4%保持体重稳定，24.2%实现体重减轻。 结论：本研究数据为PINK! Coach应用程序使用者群体及其对BMI与体力活动的影响提供了重要启示。当前临床实践中，能够有效鼓励所有乳腺癌患者参与适度体力活动并控制体重的干预方案较为有限，且多数方案仅适用于特定患者群体。本研究数据涵盖全年龄段、各肿瘤分期及治疗方式的患者，为综合干预策略提供了初步依据。未来需要通过更长期的随访数据，将研究结果置于当前学术背景下进行更深入的解读。
App-Based Lifestyle Intervention (PINK! Coach) in Breast Cancer Patients—A Real-World-Data Analysis
肿瘤(癌症)患者之家