Prehabilitation is an upcoming strategy to optimize patient’s functional capacity, nutritional status, and psychosocial well-being in order to reduce surgical complications and enhance recovery. This study aims to assess the feasibility of implementing a multimodal prehabilitation program into the standard care of gynecological oncology patients at an academic hospital in terms of recruitment, adherence, and safety, which were assessed by the number of patients eligible, recruitment rate, participation rate, and adherence to individual modalities. Data were derived from the F4S PREHAB trial, a single-center stepped-wedge trial implementing a multimodal prehabilitation program among various surgical specialties. All patients undergoing elective surgery as part of treatment for ovarian, uterine, and vulvar cancer at the Radboudumc, an academic hospital in The Netherlands, between May 2022 and September 2023 were considered eligible for the F4S PREHAB trial and, consequently, were included in this cohort study. The multimodal prehabilitation program comprised a physical exercise intervention, nutritional intervention, psychological intervention, and an intoxication cessation program. A total of 152 patients were eligible and approached for participation of which 111 consented to participate, resulting in a recruitment rate of 73%. Participants attended an average of six exercise sessions and adhered to 85% of possible training sessions. Respectively, 93% and 98% of participants adhered to the prescribed daily protein and vitamin suppletion. Ten participants were referred to a psychologist and completed consultations. Out of nine active smokers, two managed to quit smoking. A total of 59% adhered to alcohol cessation advice. No adverse events were reported. This study demonstrates that introducing a multimodal prehabilitation program into the standard care of gynecological oncology patients is feasible in terms of recruitment and adherence, with no serious adverse events.
预康复是一种新兴策略，旨在通过优化患者的功能状态、营养状况及心理健康水平，以降低手术并发症并促进术后恢复。本研究旨在评估在学术医院妇科肿瘤患者标准护理中实施多模式预康复计划的可行性，具体从招募情况、依从性和安全性三个维度进行评估，评估指标包括符合条件患者数量、招募率、参与率及各干预模块的依从程度。数据来源于F4S PREHAB试验——一项在多外科专科中实施多模式预康复计划的单中心阶梯楔形试验。2022年5月至2023年9月期间，在荷兰学术医院Radboudumc接受卵巢癌、子宫内膜癌及外阴癌择期手术治疗的所有患者均符合F4S PREHAB试验纳入标准，并由此纳入本队列研究。多模式预康复计划包含运动训练干预、营养干预、心理干预及成瘾戒断方案。在152名符合条件并受邀参与的患者中，111人同意参与，招募率达73%。参与者平均完成6次运动训练，训练课程出席率达85%。分别有93%和98%的参与者遵循了每日蛋白质与维生素补充方案。10名参与者接受了心理转诊并完成咨询。9名现役吸烟者中有2人成功戒烟。59%的参与者遵循了戒酒建议。研究期间未报告不良事件。本研究表明，在妇科肿瘤患者标准护理中引入多模式预康复计划在招募与依从性方面具有可行性，且未发生严重不良事件。
肿瘤(癌症)患者之家