Cancer-related fatigue (CRF) is a prevalent and persistent issue affecting cancer patients, with a broad impact on their quality of life even years after treatment completion. The precise mechanisms underlying CRF remain elusive, yet its multifaceted nature involves emotional, physical, and cognitive dimensions. The absence of effective medical treatments has prompted researchers to explore integrative models for potential insights. Notably, physical exercise emerges as a promising strategy for managing CRF and related symptoms, as studies showed a reduction in CRF ranging from 19% to 40%. Current recommendations highlight aerobic training at moderate intensity as beneficial, although questions about a dose–response relationship and the importance of exercise intensity persist. Despite the positive impact of exercise on CRF, the underlying mechanisms remain elusive. This review aims to provide a theoretical model explaining how aerobic exercise may alleviate CRF. Focusing on acute exercise effects, this review delves into the potential influence on peripheral and neural inflammation, immune function dysregulation, and neuroendocrine system disruptions. The objective is to enhance our understanding of the intricate relationship between exercise and CRF, ultimately paving the way for tailored interventions and potential pharmacological treatments for individuals unable to engage in physical exercise.
癌因性疲乏是影响癌症患者的一种普遍且持续存在的问题，即使在治疗结束多年后仍对其生活质量产生广泛影响。其确切机制尚未明确，但其多维度特性涉及情感、躯体和认知层面。由于缺乏有效的医学治疗手段，研究者开始探索整合性模型以寻求潜在突破。值得注意的是，体育锻炼已成为管理癌因性疲乏及相关症状的有效策略，研究显示其可降低19%至40%的疲乏程度。当前指南强调中等强度有氧训练的益处，但关于剂量反应关系及运动强度重要性的问题仍待解答。尽管运动对癌因性疲乏具有积极影响，其内在作用机制尚未明晰。本综述旨在构建理论模型阐释有氧运动缓解癌因性疲乏的潜在路径。通过聚焦急性运动效应，深入探讨其对周围及神经炎症、免疫功能失调和神经内分泌系统紊乱的调节作用，以期深化对运动与癌因性疲乏复杂关系的理解，最终为无法进行体育锻炼的个体开发针对性干预措施及潜在药物治疗方案奠定理论基础。
肿瘤(癌症)患者之家