The Dutch guideline for patients suspected of head and neck paragangliomas (HNPGLs) recommends magnetic resonance imaging (MRI) and/or computed tomography (CT) of the head and neck area. Additionally, it suggests considering additional nuclear imaging. The aim of this study was to evaluate the outcomes of [68Ga]Ga-DOTATOC PET/CT compared to MRI in patients with suspected HNPGLs and carriers of genetic variations. Methods: In this single-center pilot study, retrospective data were obtained from consecutive patients between 2016 and 2023. Both MRI and [68Ga]Ga-DOTATOC PET/CT were performed within 12 months. The primary outcome was the location of HNPGLs. Results: A total of 25 consecutive patients were included, and 7 patients (28.0%,p= 0.5) showed differences between the imaging modalities, of whom 5 patients had unexpected localizations with additional uptake by somatostatin receptors (SSTR) on the [68Ga]Ga-DOTATOC PET/CT. Conclusions: The authors recommend performing baseline imaging with [68Ga]Ga-DOTATOC PET/CT (if available) in variant carriers and using MRI/CT for follow-up according to the regional protocol, thereby shifting the gold standard for baseline imaging from MRI/CT to [68Ga]Ga-DOTATOC PET/CT.
荷兰针对疑似头颈部副神经节瘤（HNPGLs）患者的诊疗指南推荐进行头颈部磁共振成像（MRI）和/或计算机断层扫描（CT），并建议考虑补充核医学影像检查。本研究旨在评估[68Ga]Ga-DOTATOC PET/CT与MRI在疑似HNPGLs患者及基因变异携带者中的检测结果差异。方法：本单中心试点研究回顾性收集了2016年至2023年间连续就诊患者的临床资料，所有患者均在12个月内完成MRI与[68Ga]Ga-DOTATOC PET/CT检查。主要观察指标为HNPGLs的定位情况。结果：共纳入25例连续患者，其中7例（28.0%，p=0.5）在两种影像模式间存在检测差异，其中5例患者通过[68Ga]Ga-DOTATOC PET/CT发现生长抑素受体（SSTR）异常摄取的意外病灶定位。结论：作者建议对基因变异携带者采用[68Ga]Ga-DOTATOC PET/CT（若可及）作为基线影像检查手段，并依据区域诊疗规范使用MRI/CT进行随访监测，从而将基线影像检查的金标准从MRI/CT转向[68Ga]Ga-DOTATOC PET/CT。
肿瘤(癌症)患者之家