This exploratory narrative review paper delves into the intricate interplay between per- and polyfluoroalkyl substances (PFAS) exposure, sociodemographic factors, and the influence of stressors in the context of endometrial cancer. PFAS, ubiquitous environmental contaminants notorious for their persistence in the ecosystem, have garnered attention for their potential to disrupt endocrine systems and provoke immune responses. We comprehensively examine the various sources of PFAS exposure, encompassing household items, water, air, and soil, thus shedding light on the multifaceted routes through which individuals encounter these compounds. Furthermore, we explore the influence of sociodemographic factors, such as income, education, occupation, ethnicity/race, and geographical location and their relationship to endometrial cancer risk. We also investigated the role of stress on PFAS exposure and endometrial cancer risk. The results revealed a significant impact of sociodemographic factors on both PFAS levels and endometrial cancer risk. Stress emerged as a notable contributing factor influencing PFAS exposure and the development of endometrial cancer, further emphasizing the importance of stress management practices for overall well-being. By synthesizing evidence from diverse fields, this review underscores the need for interdisciplinary research and targeted interventions to comprehensively address the complex relationship between PFAS, sociodemographic factors, stressors, and endometrial cancer.
本探索性叙述综述深入探讨了全氟及多氟烷基物质（PFAS）暴露、社会人口学因素以及压力源在子宫内膜癌背景下的复杂相互作用。PFAS作为普遍存在的环境污染物，以其在生态系统中的持久性而臭名昭著，因其可能干扰内分泌系统并引发免疫反应而备受关注。我们全面审视了PFAS暴露的多种来源，包括家居用品、水、空气和土壤，从而揭示了个体接触这些化合物的多途径方式。此外，我们探讨了收入、教育、职业、民族/种族和地理位置等社会人口学因素对子宫内膜癌风险的影响及其关联。我们还研究了压力在PFAS暴露与子宫内膜癌风险中的作用。结果显示，社会人口学因素对PFAS水平及子宫内膜癌风险均具有显著影响。压力成为影响PFAS暴露和子宫内膜癌发生的重要促进因素，进一步强调了压力管理对整体健康的重要性。通过整合多学科证据，本综述强调需要开展跨学科研究和针对性干预措施，以全面应对PFAS、社会人口学因素、压力源与子宫内膜癌之间复杂的关联。
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