文章：

生活方式因素与PTEN错构瘤综合征（PHTS）女性患者乳腺癌风险关联研究

Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)

原文发布日期：27 February 2024

DOI: 10.3390/cancers16050953

类型: Article

开放获取: 是

英文摘要：

Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020–March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0–1 times/week physical activity than ≥2 times (ORtotal-adj= 0.9 (95%CI 0.3–2.6); consumed daily about 1.2–1.8 times more often ≥1 than 0–1 glasses of alcohol (ORtotal-adj= 1.2 (95%CI 0.4–4.0); ORnon-breastcancer-index-adj= 1.8 (95%CI 0.4–6.9); were about 1.04–1.3 times more often smokers than non-smokers (ORtotal-adj= 1.04 (95%CI 0.4–2.8); ORnon-breastcancer-index-adj= 1.3 (95%CI 0.4–4.2)); and overweight or obesity (72%) was about 1.02–1.3 times less common (ORtotal-adj= 0.98 (95%CI 0.4–2.6); ORnon-breastcancer-index-adj= 0.8 (95%CI 0.3–2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients’ breast cancer risk is important.

摘要翻译： 

患有PTEN错构瘤肿瘤综合征（PHTS）的女性乳腺癌风险高达76%。本研究评估了欧洲成年女性PHTS患者中乳腺癌与生活方式之间的关联。数据通过患者问卷（2020年7月至2023年3月）和医疗档案中的基因诊断收集。生活方式与乳腺癌之间的关联采用经年龄校正的逻辑回归计算。为纠正确认偏倚，排除了在PHTS诊断前已患乳腺癌的索引患者（乳腺癌索引）。共纳入125名患者，其填写问卷时的平均年龄为44岁（标准差=13）。其中包括21名乳腺癌索引患者（17%）和39名在平均43岁（标准差=9）时罹患乳腺癌的女性。乳腺癌患者每周进行0-1次体力活动的频率约为≥2次者的1.1倍（总校正OR=0.9（95%CI 0.3-2.6））；每日饮酒≥1杯的频率约为0-1杯者的1.2-1.8倍（总校正OR=1.2（95%CI 0.4-4.0）；非乳腺癌索引校正OR=1.8（95%CI 0.4-6.9））；吸烟者频率约为非吸烟者的1.04-1.3倍（总校正OR=1.04（95%CI 0.4-2.8）；非乳腺癌索引校正OR=1.3（95%CI 0.4-4.2））；而超重或肥胖（72%）的频率约降低1.02-1.3倍（总校正OR=0.98（95%CI 0.4-2.6）；非乳腺癌索引校正OR=0.8（95%CI 0.3-2.7））。PHTS患者与普通人群在生活方式与乳腺癌的关联上表现出相似趋势。尽管结果未达到统计学显著性，但具有临床意义，提示关注生活方式对患者乳腺癌风险的影响至关重要。

原文链接：

Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)