Sleep is a fundamental human need; sleep disruption, in fact, causes an increase in the activity of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis, metabolic effects, changes in circadian rhythms, and pro-inflammatory responses. The scientific literature is finally starting to pay attention to the central role of sleep alterations in patients health. Oxaliplatin is extensively used for the treatment of gastrointestinal cancer and other malignancies, with an increased frequency of use in recent years. This study aims to understand the effects of sleep complaints on health and quality of life in cancer patients treated with oxaliplatin. A study has been conducted through the creation and distribution of questionnaires to patients to investigate their complaints about sleep quality. We observed significant differences between males and females in evaluating sleep hygiene scores, the Pittsburgh Sleep Quality Index, and previous difficulty sleeping. Moreover, in females, stress, worries, and anxiety seem to play a negative role in the sleep hygiene score. The obtained results could improve the interest of healthcare personnel and caregivers in sleep quality in patients undergoing chemotherapy.
睡眠是人类的基本需求；事实上，睡眠紊乱会导致交感神经系统和下丘脑-垂体-肾上腺轴活动增强、代谢效应改变、昼夜节律变化以及促炎反应加剧。科学文献终于开始关注睡眠改变对患者健康的核心影响。奥沙利铂广泛用于治疗胃肠道癌及其他恶性肿瘤，近年来使用频率显著增加。本研究旨在探讨睡眠问题对接受奥沙利铂治疗的癌症患者健康与生活质量的影响。我们通过设计并向患者发放问卷，调查了他们对睡眠质量的抱怨情况。研究发现，在睡眠卫生评分、匹兹堡睡眠质量指数及既往睡眠困难评估方面，男女性别间存在显著差异。此外，在女性患者中，压力、担忧和焦虑似乎对睡眠卫生评分产生负面影响。这些研究结果有望提升医护人员及照护者对化疗患者睡眠质量的关注度。
肿瘤(癌症)患者之家