文章：

罗马尼亚西部地区p16阳性与p16阴性口咽癌治疗及生存率的回顾性对比分析

A Retrospective Analysis from Western Romania Comparing the Treatment and Survivability of p16-Positive versus p16-Negative Oropharyngeal Cancer

原文发布日期：26 February 2024

DOI: 10.3390/cancers16050945

类型: Article

开放获取: 是

英文摘要：

Background: Oropharyngeal cancer is a global health concern due to its multifaceted nature. Recent molecular studies have linked p16 overexpression, associated with the human papillomavirus, to oropharyngeal cancer and its prognostic implications. Materials and Methods: This retrospective study in Western Romania examined 60 patients, categorizing them based on p16 biomarker status: 28 were p16 positive, and 32 were p16 negative. Statistical tests, including Fisher’s exact and chi2, were used for analysis. Results: Patients with p16-positive oropharyngeal cancer exhibited a better prognosis (3-year survival,p= 0.0477; midtreatment,p= 0.0349) and reported lower alcohol (p= 0.0046) and tobacco (p< 0.0001) use. Conclusions: The study highlights the importance of p16 testing in oropharyngeal carcinoma diagnosis. It suggests modifying treatment approaches based on p16 status and underscores the differing prognoses associated with p16-positive and p16-negative cases.

摘要翻译： 

背景：口咽癌因其多面性已成为全球健康关注点。近期分子生物学研究表明，与人乳头瘤病毒相关的p16蛋白过表达与口咽癌及其预后影响存在关联。材料与方法：本回顾性研究在罗马尼亚西部地区开展，纳入60例患者，根据p16生物标志物状态进行分组：其中28例为p16阳性，32例为p16阴性。采用Fisher精确检验和卡方检验等统计方法进行分析。结果：p16阳性口咽癌患者表现出更好的预后（3年生存率，p=0.0477；中期治疗评估，p=0.0349），且酒精（p=0.0046）和烟草（p<0.0001）使用率较低。结论：本研究强调了p16检测在口咽癌诊断中的重要性，建议根据p16状态调整治疗方案，并明确指出p16阳性与阴性病例在预后方面存在显著差异。

原文链接：

A Retrospective Analysis from Western Romania Comparing the Treatment and Survivability of p16-Positive versus p16-Negative Oropharyngeal Cancer