文章：

前列腺特异性膜抗原（PSMA）成像生物标志物在侵袭性前列腺癌中的现状分析

The Current Landscape of Prostate-Specific Membrane Antigen (PSMA) Imaging Biomarkers for Aggressive Prostate Cancer

原文发布日期：26 February 2024

DOI: 10.3390/cancers16050939

类型: Article

开放获取: 是

英文摘要：

The review examines the vital role of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) in the diagnosis, staging, and treatment of prostate cancer (PCa). It focuses on the superior diagnostic abilities of PSMA PET/CT for identifying both nodal and distant PCa, and its potential as a prognostic indicator for biochemical recurrence and overall survival. Additionally, we focused on the variability of PSMA’s expression and its impact on personalised treatment, particularly the use of [177Lu] Lu-PSMA-617 radioligand therapy. This review emphasises the essential role of PSMA PET/CT in enhancing treatment approaches, improving patient outcomes, and reducing unnecessary interventions, positioning it as a key element in personalised PCa management.

摘要翻译： 

本综述探讨了前列腺特异性膜抗原（PSMA）正电子发射断层扫描/计算机断层扫描（PET/CT）在前列腺癌（PCa）的诊断、分期及治疗中的关键作用。重点分析了PSMA PET/CT在识别淋巴结转移与远处转移方面卓越的诊断能力，及其作为生化复发与总生存期预后指标的潜力。同时，本文聚焦于PSMA表达的异质性及其对个体化治疗的影响，特别是[¹⁷⁷Lu]Lu-PSMA-617放射性配体疗法的应用。本综述强调PSMA PET/CT在优化治疗方案、改善患者预后及减少不必要干预方面的重要作用，确立了其在个体化前列腺癌管理中的核心地位。

原文链接：

The Current Landscape of Prostate-Specific Membrane Antigen (PSMA) Imaging Biomarkers for Aggressive Prostate Cancer