Locally advanced cervical cancer represents a significant treatment challenge. Body composition parameters such as body mass index, sarcopenia, and sarcopenic obesity, defined by sarcopenia and BMI ≥ 30 kg/m2, have been identified as potential prognostic factors, yet their overall impact remains underexplored. This study assessed the relationship between these anthropometric parameters alongside clinical prognostic factors on the prognosis of 173 cervical cancer patients. Survival outcomes in terms of local control (LC), distant metastasis-free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were analyzed using Kaplan regression methods—Meier and Cox. Older age, lower hemoglobin levels, higher FIGO (International Federation of Gynecology and Obstetrics) stages, and lower total radiation doses were significantly associated with worse outcomes. Univariate analysis showed a significant correlation between BMI and the outcomes examined, revealing that normal-weight patients show higher survival rates, which was not confirmed by the multivariate analysis. Sarcopenia was not correlated with any of the outcomes considered, while sarcopenic obesity was identified as an independent negative predictor of DFS (HR: 5.289, 95% CI: 1.298–21.546,p= 0.020) and OS (HR: 2.645, 95% CI: 1.275–5.488,p= 0.009). This study highlights the potential of sarcopenic obesity as an independent predictor of clinical outcomes. These results support their inclusion in prognostic assessments and treatment planning for patients with advanced cervical cancer.
局部晚期宫颈癌是临床治疗中的一大挑战。身体成分参数如体重指数、肌肉减少症以及肌肉减少性肥胖（定义为肌肉减少且体重指数≥30 kg/m²）已被确定为潜在的预后因素，但其整体影响尚未得到充分研究。本研究评估了173例宫颈癌患者中这些人体测量学参数及临床预后因素与预后的关系。采用Kaplan-Meier法和Cox回归模型分析局部控制率、无远处转移生存期、无病生存期和总生存期等生存结局。结果显示，年龄较大、血红蛋白水平较低、国际妇产科联盟分期较高以及总放射剂量较低与不良预后显著相关。单变量分析显示体重指数与所考察的结局存在显著相关性，表明体重正常患者生存率更高，但多变量分析未证实此关联。肌肉减少症与任何结局均无相关性，而肌肉减少性肥胖被确定为无病生存期（风险比：5.289，95%置信区间：1.298-21.546，p=0.020）和总生存期（风险比：2.645，95%置信区间：1.275-5.488，p=0.009）的独立负面预测因子。本研究揭示了肌肉减少性肥胖作为临床结局独立预测因子的潜力，这些结果支持将其纳入晚期宫颈癌患者的预后评估和治疗规划中。
肿瘤(癌症)患者之家